- 中文名稱
GLP-2 ELISA
- 英文名字
- GLP-2 ELISA
- 供應(yīng)商
- Ansh Labs
- 產(chǎn)品貨號(hào)
- AL-174
- 產(chǎn)品報(bào)價(jià)
- ￥詢價(jià)/96wellmicrotiter
- 產(chǎn)品說明書
- 點(diǎn)擊查看
- 購買方式
- 90%產(chǎn)品中國有現(xiàn)貨庫存。銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868
- 產(chǎn)品新聞
- 背景資料
- Glucagon-Like Peptide-2 (GLP-2) is a 33-amino acid gut hormone produced by the intestinal L-cells and various neurons in the central nervous system1-3. Posttranslational proteolytic cleavage of proglucagon molecule produces GLP-2 along with GLP-1. Intestinal GLP-2 is co-secreted along with GLP-1 upon nutrient ingestion. GLP-2 is released in response to stimulation by luminal nutrients, such as glucose, fatty acids and dietary fiber4. GLP-2 is cleaved by proteolytic enzymes into active form (1-33) and inactive form (3-33). The GLP-2 sequence is highly conserved among mammals and is involved in regulating gut mucosal growth and integrity. The main biological actions of GLP-2 are related to the regulation of energy absorption and maintenance of mucosal morphology, function and integrity of the intestine; however, recent experimental animal studies suggested that GLP-2 exerts beneficial effects on glucose metabolism in conditions related to increased uptake of energy, such as obesity. GLP-2 acts in an endocrine fashion to link intestinal growth and metabolism with nutrient intake4. GLP-2 acts as a beneficial factor for glucose metabolism in mice with high-fat diet-induced obesity5. GLP-2 and related analogs may be used as therapeutics for short bowel syndrome, Crohn's disease, osteoporosis and as adjuvant therapy during cancer chemotherapy. Measuring plasma levels of GLP-2 in research, preclinical and clinical studies of Type 2 Diabetes and obesity will open new avenue for diagnostics and therapeutics.
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nReferences:
n1. Müller et al., (2017) The New Biology and Pharmacology of Glucagon. Physiol Rev 97: 721–766.
n2. Drucker DJ, Habener JF, Holst JJ Discovery, characterization, and clinical development of the glucagon-like peptides (2017) J Clin Invest. 127(12):4217-4227.
n3. Vrang N, Hansen M, Larsen PJ & Tang-Christensen M 2007 Characterization of brainstem preproglucagon projections to the paraventricular and dorsomedial hypothalamic nuclei. Brain Research 1149 118–126
n4. Amato A, Baldassano and Flavia Mulè. GLP2: an underestimated signal for improving glycaemic control and insulin sensitivity. Journal of Endocrinology (2016) 229, R57–R66
n5. Baldassano S, Amato A, Rappa F, Cappello F & Mulè F (2016b) Influence of endogenous glucagon like peptide-2 on lipid disorders in mice fed a high fat diet. Endocrine Research.
nVol. 41, Iss. 4,
n6. HHS Publication, 5th ed., 2007. Biosafety in Microbiological and Biomedical Laboratories. Available http://www.cdc.gov/biosafety/publications/bmbl5/BMBL5
n7. DHHS (NIOSH) Publication No. 78–127, August 1976. Current Intelligence Bulletin 13 - Explosive Azide Hazard. Available: http:// www.cdc.gov/niosh.
n8. Kricka L. Interferences in immunoassays – still a threat. Clin Chem 2000; 46: 1037–1038.
- 產(chǎn)品描述
- The Glucagon-like peptide-2 (GLP-2) enzyme linked immunosorbent assay (ELISA) kit provides materials for the quantitative measurement of GLP-2 in EDTA plasma and other biological fluids.
- 產(chǎn)品特點(diǎn)
- 保存建議
- Store at 2 to 8°C until expiration date.
- 其他
- Ansh labs是開發(fā)和生產(chǎn)免疫檢測(cè)試劑盒和定制生物技術(shù)檢測(cè)產(chǎn)領(lǐng)創(chuàng)者，總部位于美國休斯敦，公司產(chǎn)品遍及全球80多個(gè)國家。公司于2011年成立，核心團(tuán)隊(duì)來自于Diagnostic system laboratory，專注于女性健康和激素檢測(cè)領(lǐng)域近40年，擁有全球領(lǐng)先的核心技術(shù)， 以及多年經(jīng)驗(yàn)生物技術(shù)研發(fā)經(jīng)驗(yàn)的科學(xué)家團(tuán)隊(duì)，產(chǎn)品覆蓋生殖健康，高危妊娠，腫瘤，糖尿病等多個(gè)疾病領(lǐng)域，圍繞最新的免疫分析技術(shù)，多種蛋白和單克隆抗體，如AMH，BMP-15, Follistatin, GDF-9, IGF-I, IGF-II, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, Inhibin Alpha, Inhibin ?A, Inhibin ?B, MBP, PAPP-A, PAPP-A2 and Vitamin D.等幾十余種試劑產(chǎn)品，也同時(shí)涵蓋小鼠，大鼠，狗，羊，牛等靈長類多個(gè)物種的獨(dú)特的物種特異性的試劑。
Ansh labs 坐落于美國德克薩斯州，是目前世界上唯一能提供TGF-β超家族所有成員的檢測(cè)公司，也是最早專注激素類產(chǎn)品研究和新型免疫檢測(cè)技術(shù)的先驅(qū)者。優(yōu)勢(shì)產(chǎn)品涉及TGF-β super family、AMH/抑制素B(human/animal)、full panel IGFs、以及最完整的胰高血糖素系列。
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- 注意
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該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說明書為準(zhǔn)。下單前，請(qǐng)瀏覽說明書確認(rèn)。
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