大鼠TRPV1（胞外）-ATTO-488抗體（50 ul）-Anti-rat TRPV1 （extracellular)-ATTO-488代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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背景資料: TRP channels are a large family (about 28 genes) of plasma membrane, non-selective cationic channels that are either specifically or ubiquitously expressed in excitable and non-excitable cells.According to IUPHAR the TRP family comprises three main subfamilies on the basis of sequence homology; TRPC, TRPM and TRPV (to date, three extra subfamilies are considered to belong to the TRP family; the TRPA, TRPML, and TRPP). The TRPV subfamily consists of six members, TRPV1-6.TRPV1 channel has many activators; among them heat, protons, vanilloids like capsaicin, resiniferatoxin (RTX), and lipids. This channel is associated with tissue injury and inflammation.TRPV1 is expressed predominantly in nociceptors and in sensory neurons.Recent studies demonstrated involvement of TRPV1 in apoptosis where inhibition of the receptor prevented apoptosis. ATTO dyes are characterized by strong absorption (high extinction coefficient), high fluorescence quantum yield, and high photo-stability. The ATTO-488 label is analogous to the well known dye fluorescein isothiocyanate (FITC) and can be used with filters typically used to detect FITC.

免疫原: rat TRPV1 (胞外)-ATTO-488抗體的免疫原肽段為(C)NSLPMESTPHK*SRGS。此免疫原序列來源于605-619 位氨基酸殘基，該序列來源于大鼠TRPV1 ，替代 cysteine 616 (C616) with serine (*S) (Accession編號為O35433)，第3胞外環(huán)。

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