葡萄糖依賴性促胰島素受體抗體（25 ul）-Anti-Glucose-Dependent Insulinotropic Receptor代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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背景資料: Glucose-dependent Insulinotropic Receptor (GPR119) is a rhodopsin-type member of the G protein-coupled receptors (GPCRs) superfamily. Like all members, it has seven transmembrane spanning domains, an extracellular N-terminus and intracellular C-terminus. Activation of the receptor leads to a rise in intracellular cAMP – suggesting a stimulation of adenylate cyclase, possibly by Gαs coupling. It is expressed mostly in enteroendocrine cells of the gastrointenstinal tract and b-cells of the pancreas. It was stipulated that GPR119 is a close relative to the cannabinoid receptors.nPhospholipids and fatty acid amides are endogenous ligands for GPR119. Notably, oleoethanolamide (OEA) seems to be an important agonist. Stimulation of GPR119 by its agonists causes b-cells to release insulin and enteroendocrine cells to release glucagon-like peptide-1 (GLP-1); this attribute makes GPR119 a strong therapeutic candidate for type-2 diabetes and obesity. Furthermore, its ability to release GLP-1 upon stimulation by dietary fat has gained it the title "fat sensor"

應(yīng)用類型: 經(jīng)驗(yàn)證，該抗體可應(yīng)用于WB等實(shí)驗(yàn)應(yīng)用，也可用于IC、IFC、IH、IP等實(shí)驗(yàn)。

免疫原: Glucose-Dependent Insulinotropic 受體抗體的免疫原肽段為CDMLK IASVHSQHIR。此免疫原序列來源于186-200 位氨基酸殘基，該序列來源于大鼠Glucose-dependent Insulinotropic 受體 (Accession編號為Q7TQN8)。第二胞內(nèi)環(huán)。

保存建議: 艾美捷為您提供的Glucose-Dependent Insulinotropic 受體抗體(25 ul)為室溫運(yùn)輸，建議您收到產(chǎn)品后﹣20℃保存。

其他: Alomone成立于1989年,已經(jīng)成為全世界科學(xué)家信賴的最全面的離子通道研究工具供應(yīng)商。產(chǎn)品覆蓋離子通道、G蛋白耦聯(lián)受體和神經(jīng)信號研究所需的一抗、小分子、蛋白質(zhì)和多肽等。所有Alomone產(chǎn)品均進(jìn)行了生物實(shí)驗(yàn)驗(yàn)證，以凍干粉形式提供，可確保產(chǎn)品生物活性和保質(zhì)期。Alomone可提供多種包裝規(guī)格，靈活方便。作為Alomone Labs在中國的區(qū)域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Alomone Labs產(chǎn)品以及客戶訂制化服務(wù)。