絲裂原活化蛋白激酶(mitogen-activated protein kinases,MAPKs)是細(xì)胞內(nèi)的一類絲氨酸/蘇氨酸蛋白激酶.研究證實(shí),MAPKs信號(hào)轉(zhuǎn)導(dǎo)通路存在于大多數(shù)細(xì)胞內(nèi),在將細(xì)胞外刺激信號(hào)轉(zhuǎn)導(dǎo)至細(xì)胞及其核內(nèi),并引起細(xì)胞生物學(xué)反應(yīng)(如細(xì)胞增殖、分化、轉(zhuǎn)化及凋亡等)的過(guò)程中具有至關(guān)重要的作用.研究表明,MAPKs信號(hào)轉(zhuǎn)導(dǎo)通路在細(xì)胞內(nèi)具有生物進(jìn)化的高度保守性,在低等原核細(xì)胞和高等哺乳類細(xì)胞內(nèi),目前均已發(fā)現(xiàn)存在著多條并行的MAPKs信號(hào)通路,不同的細(xì)胞外刺激可使用不同的MAPKs信號(hào)通路,通過(guò)其相互調(diào)控而介導(dǎo)不同的細(xì)胞生物學(xué)反應(yīng).
應(yīng)用類型
ELISA, Western blot, and Immunofluorescence
免疫原
Anti-human MAPK3 mAb, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human MAPK3 amino acids 1-137 purified from E. coli.