HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer and displays potent oncogenic activity when overexpressed. Herstatin, as the product of alternative HER-2 transcript, retains intron 8. The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2.
應(yīng)用類型
【ERBB2】兔抗人人類表皮生長因子受體II 抗體Polyclonal Rabbit Anti Human Herstatin該產(chǎn)品的應(yīng)用類型查閱產(chǎn)品說明書。
免疫原
The erbb2 antibody was raised in rabbits by immunization with the recombinant Human erbb2 (43.4 kDa, 397 a.a. and one extra AA, N-terminal Methionin) purified from E. coli.