Pancreatitis-associated protein (PAP) is a secretory protein not normally expressed in healthy pancreas but highly induced during acute pancreatitis. While PAP has been shown to be anti-bacterial and antiapoptotic in vitro, its definitive biological function in vivo is not clear. Using antisepse oligonucleotides, inhibition of PAP expression significantly worsened pancreatitis in a rat model. During pancreatitis, PAP released by the pancreas could mediate lung inflammation through induction of hepatic TNF- alpha expression and subsequent increase in circulating TNF-alpha.
應(yīng)用類型
【PAP-1】兔抗人再生胰島衍生蛋白3aPolyclonal Rabbit Anti Human Pancreatitis-associated protein 該產(chǎn)品的應(yīng)用類型查閱產(chǎn)品說明書。
免疫原
Immunoaffinity chromatography on a column with immobilized recombinant human REG3A.
來源宿主
提供的【PAP-1】兔抗人再生胰島衍生蛋白3aPolyclonal Rabbit Anti Human Pancreatitis-associated protein 產(chǎn)品,該來源宿主查看產(chǎn)品說明書。