【NKp46】小鼠抗人自然殺傷細胞表面受體NKP46抗體-Mouse Anti Human Natural Cytotoxicity Receptor NKp46代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: 【NKp46】小鼠抗人自然殺傷細胞表面受體NKP46抗體

英文名字: Mouse Anti Human Natural Cytotoxicity Receptor NKp46

供應商: Prospec

產品貨號: ANT-303

產品報價: ￥詢價/100ug ￥20ug ￥5ug

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背景資料: A natural cytotoxicity receptor （NCR） NKp46 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. The natural cytotoxicity receptors （NCRs） are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. The three known NCRs include NKp46 and NKp30， which are expressed on circulating NKcells， and NKp44， which is expressed only on activating NK cells. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells， pathogen-infected cell lines and mononuclear phagocytes infected with an intracellular bacterium. The Lysis of tumor cells by NK-cells involves recognition by NKp46 of heparan sulfate moieties of membrane heparan sulfate proteoglycans. Furthermore， NKp46 is a surface receptor involved in NK-cell cell death by apoptosis. NKp46 has two extracellular Ig-like domains followed by a ~40 residue stalk region， a type I transmembrane domain， and a short cytoplasmic tail. The extracellular Ig-like domain of NKp46 （22-255aa） is purified by FPLC gel-filtration chromatography， after refolding of the isolated inclusion bodies in a redox buffer. In addition， engagement of the antigen with the monoclonal antibody stimulates intracellular calcium levels and the synthesis of cytokines. CD59 is an NKp46 coreceptor （by physical association） together they activate cytotoxicity of human NK-cells， their engagement results in tyrosine phosphorylation of CD3-zeta chains associated with NKp46. Reduced cell surface expression of NKp46 and other NK-cell receptors is linked to the impaired NK-cell cytolytic function in viremic HIV-1 infection.

應用類型: flow cytometric analysis and by Western blot

免疫原: Anti-human NKp46 mAb， is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human NKp46 amino acids 22-255 purified from E. coli.

來源宿主: 小鼠?

反應性: 人

保存建議: 4℃大約保存1個月，為長期保存，推薦保存于-20℃。請避免反復凍融。

其他: ProSpec 是一家全球著名細胞因子蛋白生產和研發(fā)的公司，具有20多年的生產經(jīng)驗，專注于蛋白（重組及合成）生產研發(fā)。我們的核心產品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。n領先的生產工藝和規(guī)模使其可以提供毫克到克級蛋白，價格優(yōu)于同類公司。絕大部分產品是天然成熟型蛋白，而不含有標簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產品沒有添加保護劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產品為凍干粉，因此易于運輸和保存。