【KIR2DS4】小鼠抗人殺傷細胞免疫球蛋白樣受體2DL4抗體-Mouse Anti Human Killer Cell Immunoglobulin-Like Receptor， 2 Domains Short Cytoplasmic Tail 4代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: 【KIR2DS4】小鼠抗人殺傷細胞免疫球蛋白樣受體2DL4抗體

英文名字: Mouse Anti Human Killer Cell Immunoglobulin-Like Receptor， 2 Domains Short Cytoplasmic Tail 4

供應(yīng)商: Prospec

產(chǎn)品貨號: ANT-304

產(chǎn)品報價: ￥詢價/100ug ￥20ug ￥5ug

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背景資料: Killer-cell immunoglobulin-like receptors （KIRs）， are a family of cell surface glycoproteins found on Natural Killer （NK） Cells， which are important cells of the immune system. They control the killing function of these cells by interacting with MHC class I molecules， which are expressed on all cell types. This interaction allows them to identify virally infected cells or tumor cells that have a distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory， which means that their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. The KIR genes are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex （LRC）. KIR molecules are extremely polymorphic， meaning their gene sequences differ significantly between individuals， so that different individuals have different arrays/repertoires of KIR genes. The KIR proteins are categorized by the number of extracellular immunoglobulin domains （2D or 3D） and by whether they have a long （L） or short （S） cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif （ITIM）. Whereas KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. KIR2DS4 is an activating Killer Cell Ig-like Receptor （KIR， previously called p50 KIR， p50.3， cl39， or KAR-K1）， which may recognize class I MHC molecules. KIR2DS4 does not inhibit the activity of NK cells.

應(yīng)用類型: ELISA， Western blot?

免疫原: Anti-human KIR2DS4 mAb is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human KIR2DS4 purified from E. coli.

來源宿主: 小鼠?

反應(yīng)性: 人

保存建議: 4℃大約保存1個月，為長期保存，推薦保存于-20℃。請避免反復(fù)凍融。

其他: ProSpec 是一家全球著名細胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。n領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白，價格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運輸和保存。