高遷移率族蛋白B1(high mobility group protein,HMGB1)是一種高度保守的核蛋白,廣泛分布于哺乳動(dòng)物細(xì)胞.隨著其晚期促炎作用的發(fā)現(xiàn),HMGB1成為近年來(lái)危重醫(yī)學(xué)研究的熱點(diǎn)之一.本文就其家族分類、基因和蛋白結(jié)構(gòu)、細(xì)胞生物學(xué)效應(yīng)方究進(jìn)展進(jìn)行綜述.
應(yīng)用類型
ELISA, Western blot and immunohistochemistry?
免疫原
Anti-human HMGB1 mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HMGB1 amino acids 1-215 purified from High Five (Trichoplusia ni) insect cells.