腫瘤壞死因子(Tumor Necrosis Factor,TNF)可分為TNF a和TNFB兩種,前者來(lái)自單核巨噬細(xì)胞,后者由活化T細(xì)胞產(chǎn)生,是具有重要生物活性的細(xì)胞因子.存在于細(xì)胞上的TNF 受體主要有兩種:TNFRⅠ和TNFRⅡ,血清中存在的是可溶性的TNFR(s TNFRⅠ, s TNFRⅡ),它們的相互作用不僅對(duì)多種腫瘤細(xì)胞有細(xì)胞毒作用,還與炎癥和發(fā)熱反應(yīng)、關(guān)節(jié)炎、敗血癥及多發(fā)性硬化等疾病有密切關(guān)系
應(yīng)用類型
ELISA,WB
免疫原
Anti-human LITAF mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human LITAF amino acids 1-161 purified from E. coli.