If you want to perform click reactions in organic media using e.g. CuBr as catalytic source, TBTA (Tris((3-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine) is the right ligand to use. It speeds-up the reactions plus maintaining the Cu(I) oxidation state of the copper source to protect your biomolecules from damage and degradation.