中文名稱

爛烴-C8-pApG

英文名字

Alkyne-C8-pApG

供應商

Baseclick

產(chǎn)品貨號

BCT-41-S

產(chǎn)品報價

￥詢價/1umol

產(chǎn)品說明書

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購買方式

銀行轉賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868

產(chǎn)品新聞

背景資料

爛烴-C8-pApG(Alkyne-C8-pApG)背景資料,請查看該產(chǎn)品的使用說明書

產(chǎn)品描述

In molecular biology, the 5′-cap structure of mRNA plays a central role in the stability of mRNA and in the initiation of translation traditional methods for synthesizing cap analogs are often labor-intensive, producing low yields and time-consuming. However, recent advances have introduced a new approach using click chemistry, specifically copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), to produce phosphate-modified cap analogs.This innovative method enables the efficient synthesis of 5′-cap mimics by combining two nucleotide units, resulting in a linear dinucleotide cap analog, with a free clickable moiety. Like our alkyne-C8-5′- phosphoadenylyl- (3′ ?> 5′)- guanosine (pApG or 5′-p(rA)p(rG)). This enables you to produce easy different cap structures by clicking to conventional cap structures with corresponding azide modified nucleotide.In addition, click labeling of mRNA at 5’-end with e.g. targeting agents, protective entities to prevent degradation, or fluorescent dyes. These cap analog not only increase mRNA stability but also improve translation efficiency, making them highly valuable for research and therapeutic applications, including RNA-based vaccines and gene replacement therapies.Several cap analogs have been identified, when incorporated into mRNA, exhibit comparable translational efficiency after clicking to conventional cap structures. This breakthrough opens new possibilities for the development of chemically modified mRNAs that can be used in various biomedical applications, offering a promising future for mRNA-based treatments.

產(chǎn)品形式

Liquid

保存建議

-20 °C, 避光, 干燥, 無RNA酶

其他

Baseclick于2008成立于2008年德國慕尼黑，BaseClick的核心競爭力源于其專有的銅催化疊氮-炔環(huán)加成（CuAAC）點擊化學技術。該技術由2001年諾貝爾化學獎得主Barry Sharpless教授發(fā)明，BaseClick擁有在核酸領域應用該技術的全球獨家許可。相比傳統(tǒng)方法，點擊化學具有反應迅速、條件溫和、產(chǎn)率高、選擇性強等顯著優(yōu)勢，可實現(xiàn)從小分子寡核苷酸到大基因片段的高效、精準功能化修飾。目前的應用領域包括：核酸標記技術、Edu細胞增殖試驗，PCR標記試劑盒，F(xiàn)ISH探針，（高度）修飾的寡核苷酸等等，Baseclick跟Thermo Fisher，Roche，Merck，abcam，BD Bioscience等諸多知名品牌建立了合作關系。

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準確的產(chǎn)品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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