游離型可溶的RANKL Elisa試劑盒-FREE soluble RANKL HS ELISA Kit代理/參數(shù)/廠家-ELISA試劑盒-艾美捷科技有限公司

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背景資料: RANKL, the receptor activator of nuclear factor kappa B ligand, a member of the tumor necrosis factor (TNF) family (http://www.uniprot.org/uniprot/O14788), is the main stimulatory factor for the formation of mature osteoclasts and is essential for their survival. RANKL activates its specific receptor RANK, located on osteoclasts and dendritic cells. The effects are counteracted by Osteoprotegerin (OPG) which acts as an endogenous soluble receptor antagonist (see: OPG ELISA, Cat.No. BI-20403).

The major source of RANKL are osteocytes, former osteoblasts that become embedded within the mineralized bone matrix. RANKL is a ~35 kD type II transmembrane-type protein and is cleaved to release a soluble biologically active product that forms a homotrimer.

產(chǎn)品描述: Method Sandwich ELISA, HRP/TMB, 12×8-well detachable strips Sample type Serum, hepar?n plasma Sample volume 150 μl / well Assay time 2 h / overnight / 1 h / 30 min Sensitivity 0.01 pmol/l (= 0.2 pg/ml) Standard range 0 – 2 pmol/l (= 0 – 40 pg/ml) Conversion factor 1 pmol/l = 20 pg/ml (MW: 20 kDa; monomer) Specificity Endogenous and recombinant human free soluble RANKL. Precision In-between-run (n=12): ≤ 3 % CV Within-run (n=5): ≤ 5 % CV Cross-reactivity The sequence homology to various primates is >95%. It is likely that the assay can be used for these species.

其他: Biomedica Immunoassay(bmgrp)公司成立于1988年, 總部位于奧地利維也納，主要致力于研究、開發(fā)和生產(chǎn)基于ELISA方法用于臨床前研究相關(guān)標(biāo)記物檢測(cè)的工具。迄今為止Biomedica Immunoassay公司在心血管檢測(cè)及骨代謝檢測(cè)領(lǐng)域開發(fā)了一系列特色ELISA檢測(cè)試劑盒，Biomedica Immunoassay的生產(chǎn)過程符合GMP/GLP指南，并符合ISO 9001:2015管理體系，有CE認(rèn)證。Biomedica Immunoassay的產(chǎn)品根據(jù)FDA， EMEA和ICH指南進(jìn)行驗(yàn)證，并具有驗(yàn)證報(bào)告。