硬骨素(SOST)Elisa試劑盒-Sclerostin ELISA Kit代理/參數(shù)/廠家-ELISA試劑盒-艾美捷科技有限公司

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背景資料: Sclerostin is a 22.5 kDa secreted glycoprotein that functions as a potent inhibitor of Wnt signaling. It acts by binding to the Wnt-coreceptor LRP5/6 thus inhibiting bone formation by regulating osteoblast function and promoting osteoblast apoptosis. The Sclerostin protein consists of two flexible N- and C-terminal arms and a cystine-knot with three loops, whereas the second loop binds to the LRP5/6 complex. Sclerostin is classically considered to be a monomeric protein, but data from Hernandez and colleagues (Hernandez et al., 2014) postulate that circulating sclerostin has a dimeric configuration. In addition, it is not yet well documented if also Sclerostin fragments circulate, but the comparison of different Sclerostin ELISAs suggest that fragments exist as well (Dallas et al., 2013).

產(chǎn)品描述: Method Sandwich ELISA, HRP/TMB, 12×8-well detachable strips Sample type Serum, EDTA plasma, citrate plasma, hepar?n plasma, urine, cell culture supernatant Sample volume 20 μl / well Assay time 18-24 h / 1 h / 30 min Sensitivity 3.2 pmol/l (= 72 pg/ml) Standard range 0 – 240 pmol/l (= 0 – 5,400 pg/ml) Conversion factor 1 pmol/l = 22.5 pg/ml (MW: 22.5 kDa) Precision In-between-run (n=6): ≤ 10 % CV Within-run (n=8): ≤ 7 % CV Specificity Endogenous and recombinant human Sclerostin. Cross-reactivity The assay does not cross-react with Wise (Sostdc1) or Noggin. The assay does not cross-react with rat or mouse Sclerostin.

其他: Biomedica Immunoassay(bmgrp)公司成立于1988年, 總部位于奧地利維也納，主要致力于研究、開發(fā)和生產(chǎn)基于ELISA方法用于臨床前研究相關標記物檢測的工具。迄今為止Biomedica Immunoassay公司在心血管檢測及骨代謝檢測領域開發(fā)了一系列特色ELISA檢測試劑盒，Biomedica Immunoassay的生產(chǎn)過程符合GMP/GLP指南，并符合ISO 9001:2015管理體系，有CE認證。Biomedica Immunoassay的產(chǎn)品根據(jù)FDA， EMEA和ICH指南進行驗證，并具有驗證報告。