成纖維細(xì)胞生長因子23(C端) Elisa試劑盒-FGF23 (C-terminal) multi-matrix ELISA Kit代理/參數(shù)/廠家-ELISA試劑盒-艾美捷科技有限公司

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背景資料: FGF23 (fibroblast growth factor 23) is a member of the fibroblast growth factor family and controls phosphate and vitamin D homeostasis. The full-length protein comprises 251 amino acids including a 24 amino acid signal peptide. The N-terminal FGF homology region of FGF23 is separated from the unique C-terminal region by a proteolytic cleavage site. A proportion of FG23 is proteolytically processed between arginine179 and serine180 to generate N-terminal and C-terminal fragments. Therefore, the major forms of FGF23 present in human circulation are hormonally intact FGF23 and inactive N-terminal and C-terminal fragments. FGF23 binds to FGF receptor 1c (FGFR1c) with its N-terminal region, while the C-terminal region is capable of interacting with the co-receptor αKlotho to confer high-affinity binding to the receptor. FGFR1c and αKlotho are expressed in the distal nephron and the parathyroid gland. Co-receptor independent signaling of FGF23 has been described for other FGFRs, which are expressed in a variety of tissues. The main source of FGF23 are osteocytes in the bone.

產(chǎn)品描述: Method Sandwich ELISA, HRP/TMB, 12×8-well detachable strips Sample type Serum, EDTA plasma, citrate plasma, heparin plasma Sample volume 50 μl / well Assay time 20-24 h / 1 h / 30 min Sensitivity 0.08 pmol/l (= 0.6 pg/ml) Standard range 0 – 20 pmol/l (= 150.4 pg/ml) Conversion factor 1 pmol/l = 7.52 pg/ml (MW: 7.52 kDa) Specificity Human FGF23 (Intact and C-terminal fragments of endogenous and recombinant human FGF23) Precision In-between (n=10): ≤ 10 % CV Within-run (n=6): ≤ 12 % CV

其他: Biomedica Immunoassay(bmgrp)公司成立于1988年, 總部位于奧地利維也納，主要致力于研究、開發(fā)和生產(chǎn)基于ELISA方法用于臨床前研究相關(guān)標(biāo)記物檢測的工具。迄今為止Biomedica Immunoassay公司在心血管檢測及骨代謝檢測領(lǐng)域開發(fā)了一系列特色ELISA檢測試劑盒，Biomedica Immunoassay的生產(chǎn)過程符合GMP/GLP指南，并符合ISO 9001:2015管理體系，有CE認(rèn)證。Biomedica Immunoassay的產(chǎn)品根據(jù)FDA， EMEA和ICH指南進(jìn)行驗(yàn)證，并具有驗(yàn)證報(bào)告。