重組FGF酸性，小鼠-RecombinantFGF-acidic,Mouse代理/參數(shù)/廠家-細(xì)胞因子-艾美捷科技有限公司

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背景資料: Fibroblast Growth Factor- acidic (FGF-acidic) is a mitogen targeting at the endothelial cells, and belongs to the heparin binding FGF family, which contains 22 members. FGF-acidic binds to the receptor family FGFR1-4 in vivo with the assistance of heparin. However, along with FGF -basic, FGF-acidic lacks the signal peptide segment, and thus is not secreted via endoplasmic reticulum (ER) and Golgi bodies. Studies have shown that FGF-acidic is highly regulated, and it is a direct angiogenesis factor. If unregulated, angiogenesis could contribute to several diseases including arthritis, diabetes, ocular neovascularization, and especially tumors. Therefore, FGF-acidic is treated as a potential oncogene, and its overexpression is correlated tightly with several cancers. Recombinant mouse Fibroblast Growth Factor- acidic (rmFGF-acidic) produced in E.coli is a single non-glycosylated polypeptide chain containing 140 amino acids. A fully biologically active molecule, rmFGF-acidic has a molecular mass of 15.8 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.

序列: FNL PLGNYKKPKL LYCSNGGHFL RILPDGTVDG TRDRSDQHIQ LQLSAESAGE VYIKGTETGQ YLAMDTEGLL YGSQTPNEEC LFLERLEENH YNTYTSKKHA EKNWFVGLKK NGSCKRGPRT HYGQKAILFL PLPVSSD

保存建議: Lyophilized recombinant mouse Fibroblast Growth Factor- acidic (rmFGF-acidic) remains stable up to 6 months at -80

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