中文名稱

重組DKK-1，小鼠

英文名字

RecombinantDKK-1,Mouse

供應(yīng)商

Bioworld

產(chǎn)品貨號(hào)

BK0193

產(chǎn)品報(bào)價(jià)

￥詢價(jià)/10ug

產(chǎn)品說(shuō)明書(shū)

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購(gòu)買方式

銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868

產(chǎn)品新聞

背景資料

Dickkopf related protein 1 (DKK1) is a chemokine that belongs to the DKK protein family, which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. It is one of the most up-regulated genes during androgen-potentiated balding, with DKK-1 messenger RNA up-regulated a few hours after DHT treatment of hair follicles at the dermal papilla in vitro. Neutralizing bodies against DKK-1 reverses DHT effects on outer root sheath keratinocytes. DKK-1 expression is attenuated by L-threonate, a metabolite of ascorbate in vitro. DKK-1 promotes LRP6 internalization and degradation as it forms a ternary complex with the cell surface receptor Kremen. DKK-1 not only functions in head formation during development, but also regulates joint remodeling and bone formation indicating its potential role in the pathogenesis of rheumatoid arthritis and multiple myeloma.Recombinant Mouse Dickkopf-related protein 1 produced in CHO cells is a polypeptide chain containing 243 amino acids. A fully biologically active molecule, rmDKK-1 has a molecular mass of 19~20 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.

序列

SATLNSVLINSNAIKNLPPPLGGAGGQPGSAVSVAPGVLYEGGNKYQTLDNYQPYPCAEDEE CGSDEYCSSPSRGAAGVGGVQICLACRKRRKRCMRHAMCCPGNYCKNGICMPSDHSHFPR GEIEESIIENLGNDHNAAAGDGYPRRTTLTSKIYHTKGQEGSVCLRSSDCAAGLCCARHF WSKICKPVLKEGQVCTKHKRKGSHGLEIFQRCYCGEGLACRIQKDHHQASNSSRLHTCQR H

來(lái)源宿主

CHO

溶解建議

Reconstituted in ddH2O or PBS at 100 μg/ml.

保存建議

Lyophilized recombinant Mouse Dickkopf-related protein 1 remains stable up to 6 months at -80

其他

Bioworld是專一服務(wù)于生命科學(xué)研究的專業(yè)技術(shù)型企業(yè)，Bioworld品牌創(chuàng)立以來(lái)?yè)碛?0000多種常規(guī)產(chǎn)品現(xiàn)貨，現(xiàn)有8000多種現(xiàn)貨抗體，以及其他IVD原料，蛋白等現(xiàn)貨產(chǎn)品。在細(xì)胞信號(hào)通路、免疫學(xué)、蛋白組學(xué)上擁有顯著優(yōu)勢(shì)，其抗體產(chǎn)品、生長(zhǎng)因子、IVD原料等為生命科學(xué)科研工作者提供了極大的便利

注意

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