中文名稱

【rSDF 1a】重組大鼠胚胎細胞衍生因子-1α

英文名字

Recombinant Rat Stromal Cell-Derived Factor-1 alpha (CXCL12)

供應(yīng)商

ProSpec

產(chǎn)品貨號

CHM-354

產(chǎn)品報價

￥詢價/10ug   ￥1mg   ￥2ug

產(chǎn)品說明書

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購買方式

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產(chǎn)品新聞

背景資料

SDF-1 （stromal cell-derived factor-1） is small cytokine belonging to the chemokine family that is officially designated Chemokine （C-X-C motif） ligand 12 （CXCL12）. It is produced in two forms， SDF-1?/CXCL12a and SDF-1?/CXCL12b， by alternate splicing of the same gene. Chemokines are characterized by the presence of four conserved cysteines， which form two disulfide bonds. The CXCL12 proteins belong to the group of CXC chemokines， whose initial pair of cysteines are separated by one intervening amino acid. CXCL12 is strongly chemotactic for lymphocytes and has been implicated as an important cell co-ordinator during development. During embryogenesis it directs the migration of hematopoietic cells from foetal liver to bone marrow. Mice which were knocked-out for CXCL12 gene were lethal before the birth or within just 1 hour of life. As another role， CXCL12a alters also the electrophysiology of neurons. CXCL12 was shown to be expressend in many tissues in mice （including brain， thymus， heart， lung， liver， kidney， spleen and bone marrow）.
The receptor for this chemokine is CXCR4， which was previously called fusin. This CXCL12-CXCR4 interaction used to be considered exclusive （unlike for other chemokines and their receptors）， but recently it was suggested that CXCL12 is also bound by CXCR7 receptor.
The gene for CXCL12 is located on human chromosome 10. In human and mouse both CXCL12 and CXCR4 show high identity of sequence: 99% and 90%， respectively.

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來源宿主

大腸桿菌中重組表達

溶解建議

提供的大鼠基質(zhì)細胞衍生因子-1α（rSDF 1a）產(chǎn)品為過濾滅菌的白色凍干粉末；該凍干粉末是從含1mg/ml大鼠基質(zhì)細胞衍生因子-1α（rSDF 1a）的20mM磷酸鹽緩沖液（pH 7.4），150mM NaCl中過濾滅菌并凍干產(chǎn)生的.我們建議加無菌的18MΩ-cm水以配制工作儲存液到不低于100ug/ml，后繼實驗過程中可根據(jù)實驗要求進一步稀釋.

保存建議

大鼠基質(zhì)細胞衍生因子-1α（rSDF 1a）凍干粉末在室溫可保存3周，或置于-18℃凍存用于長期保存.重新溶解后可以在4℃冷藏保存至少2-7天；如果想延長保存時間，建議分裝（加載體蛋白如0.1% HSA或 BSA）后置于-18℃凍存.請避免反復(fù)凍融.

其他

ProSpec 是一家全球著名細胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白，價格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運輸和保存。

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準確的產(chǎn)品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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