Insulin-like growth factor-binding protein 4 (IGFBP-4) belongs to the insulin-like growth factor binding protein (IGFBP) family. IGFBP4 includes an IGFBP domain and a thyroglobulin type-I domain. IGFBP4 binds both insulin-like growth factors (IGFs) I and II. IGFBP-4 circulates in the plasma in both glycosylated and non-glycosylated forms. IGFBPs can either inhibit or enhance the biological activities of IGF,or act in an IGF independent manner. IGFBP-4 is exceptional since it consistently inhibits several cancer cells in vivo and in vitro,suggesting that it may function as an apoptotic factor. IGFBP4 is produced by all colon cancer cells. Binding of IGFBP-4 prolongs the half-life of the IGFs and changes their interaction with cell surface receptors.
人胰島素樣生長因子結(jié)合蛋白-4產(chǎn)品在室溫條件下可以保存3周,應(yīng)該置于-18℃或更低溫度下干燥保存.
Upon reconstitution IGFBP-4 should be stored at 4°C between 2-7 days and for future use below -18°C.
推薦添加載體蛋白 (0.1% HSA或BSA)以長期保存,請避免反復(fù)凍融.