中文名稱

【rVEGF C（152a.a.）】重組大鼠血管內(nèi)皮生長因子-C（152aa）

英文名字

Recombinant Rat Vascular Endothelial Growth Factor-C (152)

供應(yīng)商

ProSpec

產(chǎn)品貨號

CYT-284

產(chǎn)品報價

￥詢價/10ug   ￥1mg   ￥2ug

產(chǎn)品說明書

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產(chǎn)品新聞

背景資料

VEGF-C152S is a point mutant generated by the replacement of the second conserved Cys residue of the recombinant processed VEGF-C by a Ser residue. VEGF-C 152S is analog to the human VEGF-C 156S mutant and only active toward VEGFR-3/FLT-4 but，unlike wild type VEGF-C，is unable to bind to and to activate signaling through VEGFR-2/KDR. VEGF-C152S was inactive in the vascular permeability assay and did not increase migration of the capillary endothelial cells，indicating that these VEGF-like effects of VEGF-C require VEGFR-2 binding. VEGF-C，also known as Vascular Endothelial Growth Factor Related Protein （VRP），is a recently discovered VEGF growth factor family member that is most closely related to VEGF-D. The rat VEGF-C cDNA encodes a pre-pro-protein of 416 amino acids residues. It is almost identical to the mouse VEGF-C protein. Similar to VEGF-D，VEGF-C has a VEGF homology domain spanning the middle third of the precursor molecule and long N- and C-terminal extensions. In adults，VEGF-C is highly expressed in heart，placenta，ovary and small intestine. Recombinant rat VEGF-C，lacking the N- and C-terminal extensions and containing only the middle VEGF homology domain，forms primarily non-covalently linked dimers. This protein is a ligand for both VEGFR-2/KDR and VEGFR-3/FLT -4. Since VEGFR-3 is strongly expressed in lymphatic endothelial cells，it has been postulated that VEGF-C is involved in the regulation of the growth and/or differentiation of lymphatic endothelium. Although recombinant rat VEGF-C is also a mitogen for vascular endothelial cells，it is much less potent than VEGF-A.

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來源宿主

桿狀病毒系統(tǒng)重組表達(dá)-昆蟲Sf9細(xì)胞中重組表達(dá)

溶解建議

提供的大鼠血管內(nèi)皮生長因子-C（152aa）（rVEGF C （152a.a.））產(chǎn)品為過濾滅菌的白色凍干粉末；該凍干粉末是從含1mg/ml大鼠血管內(nèi)皮生長因子-C（152aa）（rVEGF C （152a.a.））的BSA溶液中凍干產(chǎn)生的.我們建議加無菌的18MΩ-cm水以配制工作儲存液到不低于100ug/ml，后繼實驗過程中可根據(jù)實驗要求進(jìn)一步稀釋.

保存建議

大鼠血管內(nèi)皮生長因子-C（152aa）（rVEGF C （152a.a.））在室溫可保存3周，或置于-18℃凍存用于長期保存.重新溶解后可以在4℃冷藏保存至少2-7天；如果想延長保存時間，建議分裝后置于-18℃凍存.請避免反復(fù)凍融.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細(xì)胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白，價格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護(hù)劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運輸和保存。

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。

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