Midkine (MK) is the product of a retinoic acid responsive gene,MK,and is a member of a family of heparin binding factors. It contains 121 amino acid residues including 10 conserved cysteine residues,all of which appear to be disulphide linked.
Midkine is expressed during embryogenesis,showing an expression pattern that suggests functions in neurogenesis,cell migration,secondary organogenetic induction,and mesoderm-epithelial interaction.
The widespread downregulation of MK in the adult human is reverted in a number of cancers,in which polypeptides are able to act as both transforming growth factors and promoters of angiogenesis.
Midkine (MK),induces chemotaxis of human neutrophils and was found to trigger mobilization of intracellular calcium of these cells.
Midkine induces histamine release from rat peritoneal mast cells with a rapid response in a dose dependent manner.
Midkine is also a potent stimulator of collagen and glycosaminoglycan synthesis.
序列
請(qǐng)咨詢我們客服或者請(qǐng)查看品牌官方網(wǎng)站
來源宿主
大腸桿菌中重組表達(dá)
溶解建議
提供的人中期因子(Midkine)產(chǎn)品為凍干粉末;該凍干粉末是從含0.5mg/ml人中期因子(Midkine)的0.05M磷酸鹽緩沖液和0.1M NaCl,pH 7.2中凍干產(chǎn)生的.我們建議加0.2 ml PBS pH 7.2使粉末完全溶解.