中文名稱

重組斑馬魚生長激素突變體

英文名字

Recombinant Zebrafish Growth Hormone Mutant

供應(yīng)商

ProSpec

產(chǎn)品貨號

CYT-709

產(chǎn)品報(bào)價(jià)

￥詢價(jià)/10ug

產(chǎn)品說明書

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購買方式

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產(chǎn)品新聞

背景資料

Kallikreins are serine protease enzymes having various physiological functions.
Kallikreins are implicated in carcinogenesis and have potenital as novel cancer disease biomarkers. KLK1 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. KLK1 is functionally conserved in its ability to release the vasoactive peptide， Lys-bradykinin， from low molecular weight kininogen.
Human Kallikrein-1， also called as Kallidinogenase， Kininogenase or Kininogenin， is an active protein enzyme present in saliva， pancreatic juices， and urine that catalyzes the proteolysis of bradykininogen to bradykinin.
Kallikrein-1， which derived from human or porcine， have been used as drugs for a long time， they are mainly used in the treatment f light to medium hypertension and occlusion of cerebral and surrounding blood vessels.
KLK1 demonstrates both trypsin- and chymotrypsin-like selectivities with Tyr/Arg preferred at site P1， Ser/Arg strongly preferred at P1’， and Phe/Leu at P2.
rs5517 in the KLK1 gene is considerably connected with hypertension in a Chinese Han population. KLK1 is expressed de novo in endothelial cells and mediates relaxation of human umbilical veins. The K allele of KLK1 promoter and TT genotype of TGF-beta1 are a genetic KLK1 -130 GN and -128 G-C， and the defenselessness factor contributing to progressive renal descent in Taiwanese primary vesicoureteric reflux children.
Induction of KLK1 in carotid arteriosclerosis doesn’t lead to kallikrein-kinins pathway activation. Transgenic rats expressing KLK1 have impaired renal response to acute volume expansion Endothelial cells synthesize and release active form of KLK1on the surface which is important function in maintenance of circulation homeostasis.
KLK1 participates in epidermal desquamation through cleavage of desmoglein 1 and regulation by lympho-epithelial Kazal-type-related inhibitor（LEKTI).

序列

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來源宿主

畢赤酵母中重組表達(dá)

溶解建議

提供的人激肽釋放酶-1（KLK1）產(chǎn)品為過濾滅菌的透明溶液；其中人激肽釋放酶-1（KLK1）產(chǎn)品溶解于1X PBS溶液中.

保存建議

人激肽釋放酶-1（KLK1）溶液可以在4℃冷藏保存3周；如果想延長保存時(shí)間，建議分裝后置于-18℃凍存.請避免反復(fù)凍融.

其他

ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細(xì)胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。 領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白，價(jià)格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護(hù)劑或鹽，這就對工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。

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