Galantide-Galantide代理/參數(shù)/廠家-其它-艾美捷科技有限公司

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背景資料: CAS號：138579-66- 5分子量：2198.1鹽形式：TFAP純度：90%序列（3個字母）：Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH 2序列（1個字母）：GWTLNSAGYLLGPQQFFGLM-NH 2儲存溫度：-20 °C或以下Galantide是甘丙肽和P物質(zhì)片段組成的嵌合肽，作為甘丙肽受體的可逆拮抗劑。該肽以劑量依賴性方式拮抗甘丙肽介導的對葡萄糖誘導的小鼠胰島胰島素分泌的抑制作用（IC 50 = 1.0 nM）。它拮抗甘丙肽誘導的K+電導增加（IC 50 = 4 nM）。參考文獻1）Lindskog S et al. The novel high-affinity antagonist galantide blocks the galanin-mediated inhibition of glucose-induced insulin secretion.歐洲藥理學雜志1992;210（2）：183-188.2）Mulvaney JM等人Galantide區(qū)分了泥小狗副交感神經(jīng)元中甘丙肽受體的推定亞型。歐洲藥理學雜志1995;287（1）：97-100.

產(chǎn)品描述: CAS Number: 138579-66-5Molecular Weight: 2198.1Salt Form: TFAPurity: >90%Sequence (3-letter): Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2Sequence (1-letter): GWTLNSAGYLLGPQQFFGLM-NH2Storage: -20 ?°C or belowGalantide is a chimeric peptide consisting of fragments of galanin and Substance P which acts as a reversible galanin receptor antagonist. The peptide antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets in a dose-dependant manner (IC50 = 1.0 nM). It antagonizes?? the galanin-induced increase in K+ conductance IC50 = 4 nM).References1) Lindskog S et al. The novel high-affinity antagonist galantide blocks the galanin-mediated inhibition of glucose-induced insulin secretion. Eur J Pharmacol. 1992;210(2):183-188.2) Mulvaney JM et al. Galantide distinguishes putative subtypes of galanin receptors in mudpuppy parasympathetic neurons. Eur J Pharmacol. 1995;287(1):97-100.

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