中文名稱

LY 294002（PI 3-K抑制劑）

英文名字

LY294002 (PI3-K Inhibitor)

供應(yīng)商

Echelon

產(chǎn)品貨號(hào)

EEB-B-0294

產(chǎn)品報(bào)價(jià)

￥詢價(jià)/5mg

產(chǎn)品說明書

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購買方式

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產(chǎn)品新聞

背景資料

LY 294002是磷脂酰肌醇3-激酶的選擇性細(xì)胞滲透性強(qiáng)效和特異性抑制劑（IC 50 = 1.4 μ M;純化PI 3-激酶）。在50 μ M的濃度下，它不顯著抑制PKC PKA MAP激酶S6激酶EGFrK c-src激酶PI 4-激酶DAG激酶或兔腎ATP酶。誘導(dǎo)細(xì)胞凋亡。在用fMet-Leu-Phe刺激的完整中性粒細(xì)胞中，LY 294002在50 μ M時(shí)完全消除PI 3-激酶活性，而無細(xì)胞毒性。出版物Powered by Bioz See more details on Bioz 1. Coronas-Serna JM Fernánán-Acero T Molina M Cid VJ.人源化酵母為基礎(chǔ)的工具包監(jiān)測磷脂酰肌醇3-激酶活性在單細(xì)胞和群體水平。微生物細(xì)胞2018;5（12）：545-54.2。張P步行者M(jìn)C威廉姆斯RS。癲癇發(fā)作誘導(dǎo)的PIP 3水平降低有助于抑制活性，并被丙戊酸挽救。Neurobiol Dis. 2014;62：296-306.3. Ferná necessar-Acero T Rodríguez-Escudero I Vicente F Monteiro MCn Tormo JR Cantizani J et al. A Yeast-Based In Vivo Bioassay to Screen for Class I Phosphatidylinositol 3-Kinase Specific Inhibitors.生物分子篩選雜志。2012;17（8）：1018-29.

產(chǎn)品描述

LY294002 is a selective cell permeable potent and specific inhibitor of phosphatidylinositol 3-kinase (IC50 = 1.4 ??M; purified PI 3-kinase). It does not significantly inhibit PKC PKA MAP kinase S6 kinase EGFrK c-src kinase PI 4-kinase DAG kinase or rabbit kidney ATPase at concentrations of 50 ??M. Induces apoptosis. In intact neutrophils stimulated with fMet-Leu-Phe LY294002 completely abolished PI 3-kinase activity at 50 ??M without cell toxicity.Publications Powered by Bioz See more details on Bioz1. Coronas-Serna JM Fern??ndez-Acero T Molina M Cid VJ. A humanized yeast-based toolkit for monitoring phosphatidylinositol 3-kinase activity at both single cell and population levels. Microbial Cell. 2018;5(12):545-54.2. Chang P Walker MC Williams RS. Seizure-induced reduction in PIP3 levels contributes to seizure-activity and is rescued by valproic acid. Neurobiol Dis. 2014;62:296-306.3. Fern??ndez-Acero T Rodr??guez-Escudero I Vicente F Monteiro MCn Tormo JR Cantizani J et al. A Yeast-Based In Vivo Bioassay to Screen for Class I Phosphatidylinositol 3-Kinase Specific Inhibitors. Journal of Biomolecular Screening. 2012;17(8):1018-29.

產(chǎn)品形式

保存建議

4 °C或以下

其他

Echelon 提供1200+精品特色產(chǎn)品，集中圍繞磷脂，磷脂酰肌醇相關(guān)的脂質(zhì)產(chǎn)品，多肽，抗體，活性/抑制劑篩選分析試劑盒，以及篩選結(jié)合的PIP strip，Lipid Strips/Arrays??，為研究治療諸如癌癥、糖尿病、炎癥、感染和心腦血管疾病專家提供全面有效工具。

注意

該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。

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