中文名稱(chēng)

9-叔丁基鹽酸多西環(huán)素

英文名字

9-tert-Butyl Doxycycline HCl

供應(yīng)商

Echelon

產(chǎn)品貨號(hào)

EEB-B-0801

產(chǎn)品報(bào)價(jià)

￥詢(xún)價(jià)/5mg

產(chǎn)品說(shuō)明書(shū)

點(diǎn)擊查看

購(gòu)買(mǎi)方式

銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868。

產(chǎn)品新聞

背景資料

9-叔丁基多西環(huán)素（9 TB）是一種泰特開(kāi)/關(guān)系統(tǒng)激動(dòng)劑，其能夠激活四環(huán)素反式激活因子（tTA）和反向tTA（rtTA）以及tTA響應(yīng)性啟動(dòng)子（Ptets）并充當(dāng)其誘導(dǎo)物，在本文中稱(chēng)為泰特開(kāi)關(guān)。該化合物能夠以大約10倍的功效激活泰特開(kāi)關(guān)，特別是在親脂性環(huán)境如腦和肺以及其他類(lèi)似的生物區(qū)室中。9 TB易溶于水，可以IV IP給藥，也可以在實(shí)驗(yàn)動(dòng)物的飲用水中給藥，便于隨時(shí)給藥。9 TB還發(fā)現(xiàn)了使用四環(huán)素誘導(dǎo)（tet-on）系統(tǒng)研究缺氧調(diào)節(jié)的基因表達(dá)對(duì)細(xì)胞存活的作用，其中暴露于誘導(dǎo)配體多西環(huán)素（dox）抑制線粒體中的半胱天冬酶-3切割。?2007; 2（6）：e533.2）Halterman M.W.“使用Tet-On系統(tǒng)研究凋亡相關(guān)基因的改進(jìn)方法”J. Biomol.屏幕2011; 16（3）：332-3373）Jiang D.等人“Airway Epithelial NF-kB Activation Promotes Mycoplasma pneumoniae Clearance in Mice”P(pán)LoS ONE. 2012; 7（12）：e52969.4）Furutachi S.等人“Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells”Nature Medicine 2015; doi：10.1038/nn.3989.5）Furlan G. 等（2017）。“個(gè)體神經(jīng)干細(xì)胞的終身神經(jīng)原性活動(dòng)和持續(xù)生長(zhǎng)在硬骨魚(yú)的軟腭中建立了一種由外向內(nèi)的結(jié)構(gòu)。《當(dāng)代生物學(xué)》27（21）：3288-3301。DOI：10.1016/j.cub.2017.09.0526）Alonso S. B。 等（2019）。“神經(jīng)干細(xì)胞和嗅球成年神經(jīng)發(fā)生的增加提高了對(duì)高度相似氣味的辨別力。“The EMBO Journal 38：e98791. DOI：10.15252/embj.201798791

產(chǎn)品描述

9-tert-Butyl Doxycycline (9TB) is a Tet On/Off system agonist capable of activating and acting as an inducer for the tetracycline-transactivator (tTA) and reverse tTA (rtTA) and tTA-responsive promoters (Ptets) herein known as the Tet switch. The compound is able to activate the Tet switch with approximately 10-fold greater efficacy especially in lipophilic environments such as the brain and lung and other similar biocompartments. 9TB is freely soluble in water and can be administered IV IP and in the drinking water of experimental animals allowing for ready dosing. 9TB also has found use in studying hypoxia-regulated gene expression on cell survival using the tetracycline-inducible (tet-on) system where exposure to the inducing ligand doxycycline (dox) inhibited caspase-3 cleavage in mitochondria in Publications Powered by Bioz See more details on Bioz1) Zhu P. et al. a€?Silencing and Un-silencing of Tetracycline-Controlled Genes in Neuronsa€? PLoS ONE. 2007; 2(6): e533.2) Halterman M.W. a€?An Improved Method for the Study of Apoptosis-Related Genes Using the Tet-On Systema€? J. Biomol. Screen. 2011; 16(3): 332-3373) Jiang D. et al. "Airway Epithelial NF-kB Activation Promotes Mycoplasma pneumoniae Clearance in Mice" PLoS ONE. 2012; 7(12): e52969.4) Furutachi S. et al. "Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells" Nature Medicine 2015; doi:10.1038/nn.3989.5) Furlan G. et al. (2017). "Life-Long Neurogenic Activity of Individual Neural Stem Cells and Continuous Growth Establish an Outside-In Architecture in the Teleost Pallium." Current Biology 27(21): 3288-3301. DOI:10.1016/j.cub.2017.09.0526) Alonso S. B. et al. (2019). "An increase in neural stem cells and olfactory bulb adult neurogenesis improves discrimination of highly similar odorants." The EMBO Journal 38: e98791. DOI:10.15252/embj.201798791

產(chǎn)品形式

保存建議

-20 °C或以下

其他

Echelon 提供1200+精品特色產(chǎn)品，集中圍繞磷脂，磷脂酰肌醇相關(guān)的脂質(zhì)產(chǎn)品，多肽，抗體，活性/抑制劑篩選分析試劑盒，以及篩選結(jié)合的PIP strip，Lipid Strips/Arrays??，為研究治療諸如癌癥、糖尿病、炎癥、感染和心腦血管疾病專(zhuān)家提供全面有效工具。

注意

該頁(yè)面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說(shuō)明書(shū)為準(zhǔn)。下單前，請(qǐng)瀏覽說(shuō)明書(shū)確認(rèn)。

分享到：