93-O 17 S是一種用于產(chǎn)生脂質(zhì)納米顆粒以遞送RNA肽和核苷酸的類胡蘿卜素。93- 017 S LNP能夠在小鼠中遞送Cre重組酶mRNA。此外,LNP能夠?qū)re重組酶蛋白和Cas9:單向?qū)NA遞送到細(xì)胞中用于基因組編輯。93-O 17 S LNP用于在注射到小鼠B16 F10腫瘤中時遞送STING途徑激動劑2 - 3-環(huán)GMP-AMP(cGAMP),其具有作為原位癌癥疫苗的潛力。
產(chǎn)品描述
93-O17S is a lipidoid used for generating lipid nanoparticles to deliver RNA peptides and nucleotides. 93-O17S LNPs were able to deliver Cre recombinase mRNA in mice. In addition LNPs were able to deliver the Cre recombinase protein and Cas9:single-guide RNA into cells for genome editing. 93-O17S LNPs were used to deliver the STING pathway agonist 2a€23a€2-Cyclic GMP-AMP (cGAMP) when injected into B16F10 tumors in mice which has potential as an in situ cancer vaccine.