TSTA3 is a NADP(H)-binding protein. TSTA3 catalyzes the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of numerous fucosyltransferases that take part in the expression of several glycoconjugates, including blood group ABH antigens and developmental adhesion antigens.
Mutations in TSTA3 result in leukocyte adhesion deficiency, type II.
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來源宿主
大腸桿菌中重組表達
溶解建議
提供的人組織特異移植抗原P35B(TSTA3)產(chǎn)品為過濾滅菌的無色溶液;其中0.5mg/ml人組織特異移植抗原P35B(TSTA3)產(chǎn)品溶解于20mM Tris pH 8, 2mM DTT, 0.05M NaCl,10%甘油溶液中.