【TIMP1 HEK】重組人組織體內(nèi)金屬蛋白酶抑制劑1，HEK表達(dá)-Recombinant Human Tissue Inhibitor of Metalloprotease 1, HEK代理/參數(shù)/廠家-酶-艾美捷科技有限公司

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背景資料: TIMP1 is a member of the TIMP family. TIMP1 is an inducible glycoprotein produced by various cell types. The TIMP1 glycoprotein is a natural inhibitor of the matrix metalloproteinases， which a group of peptidases involved in degradation of the extracellular matrix. TIMP1 binds in a reversible mode to MMPs， with regions in the N-terminal domain binding to the MMP substrate-binding site. On top of its inhibitory function against most of the known MMPs， TIMP1 is able to promote cell proliferation in a broad range of cell types， and may also have an anti-apoptotic role. Furthermore， TIMP1 has erthyroid-potentiating activity via translocation to the nucleus and also inhibits apoptosis in B-cells. The TIMP1 gene is situated within intron 6 of the synapsin I gene and is transcribed in the opposite direction. TIMP1 activity is dependent on the existence of disulfide bonds. TIMP1 transcription is extremely inducible in reaction to many cytokines and hormones. Increased TIMP1 levels are connecte

溶解建議: 提供的人組織基質(zhì)金屬蛋白酶抑制劑1，HEK表達(dá)（TIMP1 HEK）產(chǎn)品為經(jīng)0.2um孔徑過(guò)濾滅菌的白色凍干粉末；該凍干粉末是從含人組織基質(zhì)金屬蛋白酶抑制劑1，HEK表達(dá)（TIMP1 HEK）的溶液（不含添加劑和保存劑）中過(guò)濾滅菌并凍干產(chǎn)生的.我們建議加無(wú)菌的18MΩ-cm水以配制工作儲(chǔ)存液到不低于100ug/ml，后繼實(shí)驗(yàn)過(guò)程中可根據(jù)實(shí)驗(yàn)要求進(jìn)一步稀釋.

保存建議: 人組織基質(zhì)金屬蛋白酶抑制劑1，HEK表達(dá)（TIMP1 HEK）凍干粉末在室溫可保存3周，或置于-18℃凍存用于長(zhǎng)期保存.重新溶解后可以在4℃冷藏保存至少2-7天；如果想延長(zhǎng)保存時(shí)間，建議分裝（加載體蛋白如0.1% HSA或 BSA）后置于-18℃凍存.請(qǐng)避免反復(fù)凍融.

其他: ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗(yàn)，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長(zhǎng)因子、瘦素、干細(xì)胞因子、催乳素、表皮生長(zhǎng)因子、胰島素樣生長(zhǎng)因子、神經(jīng)生長(zhǎng)因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級(jí)蛋白，價(jià)格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒(méi)有添加保護(hù)劑或鹽，這就對(duì)工藝提出了更高的要求。同時(shí)，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運(yùn)輸和保存。