人IGFBP-rP1也稱為IGFBP-7、MAC25蛋白、PG12刺激因子、前列環(huán)素刺激因子和腫瘤衍生的粘附因子。 是一種256氨基酸糖蛋白,與IGF結(jié)合蛋白具有結(jié)構(gòu)同源性。 以低親和力結(jié)合IGF-I和IGF-II,刺激前列環(huán)素產(chǎn)生并引起細(xì)胞粘附。rn該IGFBP-rP1抗體是通過用連接到白喉類毒素的來自Ig樣C2型結(jié)構(gòu)域的14個(gè)氨基酸的肽免疫兔而制備的。 該肽序列是IGFBP-rP1所特有的。 該抗體識(shí)別人IGFBP-rP1,但不識(shí)別其它IGF結(jié)合蛋白或相關(guān)蛋白。 盡管該序列來源于人IGFBP-rP1,但該抗體應(yīng)識(shí)別非人靈長類動(dòng)物、牛、羊和豬以及潛在的幾種其它物種中的IGFBP-rP1,盡管這應(yīng)通過實(shí)驗(yàn)確定。 通過蛋白A親和層析純化免疫球蛋白級(jí)分。 該抗體適用于免疫測(cè)定、免疫印跡和免疫組織化學(xué)。 Human IGFBP-rP1 is also known as IGFBP-7, MAC25 protein, PG12 stimulating factor, prostacyclin-stimulating factor and tumour derived adhesion factor. It is a 256 amino acid glycoprotein with structural homology to IGF binding proteins. It binds IGF-I and IGF-II with low affinity and stimulates prostacyclin production and causes cell adhesion.nThis IGFBP-rP1 antibody was prepared by immunising rabbits with a 14 amino acid peptide from the Ig-like C2 type domain, linked to diphtheria toxoid. The peptide sequence is unique to IGFBP-rP1. The antibody recognises human IGFBP-rP1 but no other IGF binding protein or related protein. Although the sequence is derived from human IGFBP-rP1, the antibody should recognise IGFBP-rP1 in non-human primates, cattle, sheep and pigs and potentially several other species although this should be experimentally determined. The immunoglobulin fraction was purified by Protein A affinity chromatography. The antibody is suitable for use in immunoassay, immunoblotting and immunohistochemistry.
GroPep Bioreagents公司總部位于澳大利亞,成立于1990年,致力于向廣大科研院所、生物技術(shù)及制藥公司開發(fā)、生產(chǎn)和銷售細(xì)胞培養(yǎng)級(jí)的活性生長因子(主要集中在胰島素樣生長因子(IGF)領(lǐng)域)、抗體及相關(guān)蛋白試劑,現(xiàn)有產(chǎn)品超過100多個(gè),同時(shí)在世界范圍內(nèi)均設(shè)有分銷商。公司在分子生物領(lǐng)域、發(fā)酵學(xué)及重組蛋白和單抗制備方面具有豐富的經(jīng)驗(yàn),在制造工藝方面,擁有大量專利技術(shù),GroPep目前已通過AS/NZS ISO 9001:2016質(zhì)量管理體系認(rèn)證。