HCV is a small 50nm, enveloped, single-stranded, positive sense RNAvirus in the family Flaviviridae.
HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host’s immune response. Hepatitis C virus is classified into six genotypes(1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6).
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來源宿主
大腸桿菌中重組表達
溶解建議
提供的重組丙型肝炎病毒NS4產(chǎn)品為溶液形式.該產(chǎn)品已溶解在含1.5M 尿素,0.2% Triton-X和50%甘油的25 mM Tris-HCl緩沖液(pH 8).
保存建議
Five years frozen. One month in solution at room temperature.