【附錄4】重組醋酸艾塞那肽-Recombinant Exendin-4代理/參數(shù)/廠家-蛋白標(biāo)準(zhǔn)品-艾美捷科技有限公司

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背景資料: Exedin-4 Recombinant is a glucagon like peptide-1 receptor agonist. The native hormone is produced in the gut of Gila monster Heloderma suspectrum （a type of reptile found in the desert） that stimulates insulin production without causing threateningly low blood sugar， which can occur after using insulin and some anti-diabetes products. Recently， researchers used extracted saliva from gila monsters to create an unprecedented breakthrough in Diabetes Type 2 treatment. Unlike other products taken for type 2 diabetes， Exedin-4 has not been linked with weight gain and actually resulted in weight loss， according to the researchers. Exedin-4 enhances glucose-dependant insulin secretion， suppresses inappropriately elevated glucagon secretion and slows gastric emptying in vivo. It also promotes B-cell proliferation and neogenesis in vitro and in animal models. Exedin-4 stimulates an increase in acinar cAMP， without stimulating the release of amylase.

溶解建議: 提供的重組醋酸艾塞那肽產(chǎn)品為白色無菌凍干粉末，凍干之前是在4%甘露醇糖的20mM PBS緩沖液中透析過.推薦使用無菌的18MΩ的超純水來溶解，濃度不低于100ug/ml，便于后續(xù)稀釋.

保存建議: Lyophilized Exendin Recombinant although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution Exendin-4 should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.

其他: ProSpec 是一家全球著名細(xì)胞因子蛋白生產(chǎn)和研發(fā)的公司，具有20多年的生產(chǎn)經(jīng)驗，專注于蛋白（重組及合成）生產(chǎn)研發(fā)。我們的核心產(chǎn)品包括：干擾素、白介素、骨蛋白、腫瘤壞死因子、成纖維生長因子、瘦素、干細(xì)胞因子、催乳素、表皮生長因子、胰島素樣生長因子、神經(jīng)生長因子、集落刺激因子、激素、酶、病毒抗原以及各種重組蛋白等。領(lǐng)先的生產(chǎn)工藝和規(guī)模使其可以提供毫克到克級蛋白，價格優(yōu)于同類公司。絕大部分產(chǎn)品是天然成熟型蛋白，而不含有標(biāo)簽蛋白。考慮到大部分研究者希望能更靈活地配制蛋白溶液，ProSpec-Tany絕大部分產(chǎn)品沒有添加保護(hù)劑或鹽，這就對工藝提出了更高的要求。同時，ProSpec-Tany絕大部分產(chǎn)品為凍干粉，因此易于運輸和保存。