RANKL(Receptor Activator for Nuclear Factor κ B Ligand),又稱腫瘤壞死因子相關(guān)活化誘導(dǎo)細(xì)胞因子(TRANCE)、骨保護(hù)素配體(OPGL)和破骨細(xì)胞分化因子(ODF),是腫瘤壞死因子家族細(xì)胞因子的一員。RANKL對破骨細(xì)胞的形成、活化和存活至關(guān)重要。RANKL通過與其受體RANK相互作用可調(diào)節(jié)基質(zhì)降解和炎癥。RANKL和RANK在妊娠期間淋巴結(jié)形成、胸腺微環(huán)境的建立和泌乳乳腺的發(fā)育中具有重要作用。因此,特異性靶向破骨細(xì)胞中RANK、RANKL及其信號通路的新型藥物有望徹底改變與骨丟失相關(guān)的各種疾病的治療,如關(guān)節(jié)炎、牙周病、癌癥轉(zhuǎn)移和骨質(zhì)疏松癥。 抗小鼠RANKL(IK 22/5)體內(nèi)抗體-低內(nèi)毒素該產(chǎn)品同種型對照:Rat IgG2a In Vivo Isotype Control - Low Endotoxin [1-1] (ICH2244) 緩沖液:ICH3001-100ml,nICH3002-100ml,nICH3003-100ml, 濃度:1.0 mg/ml 純度:>95% by SDS-PAGE and HPLC 內(nèi)毒素:<0.5 EU/mg as determined by the LAL method 制劑:0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
應(yīng)用類型
Flow Cytometry, Immunoprecipitation, Western Blot, Blocking, Immunofluorescence, IHC (Frozen)