CD 279,也稱為程序性死亡-1(PD-1),是一個50-55 kD的免疫球蛋白超家族成員。PD-1在CD 4-CD 8-胸腺細(xì)胞的亞群上以及在活化的T和B細(xì)胞上表達(dá)。PD-1配體PD-L1(也稱為B7-H1)和PD-L2(B7-DC)是B7免疫球蛋白超家族的成員。據(jù)報道,這種RMP 1 -14抗體可阻斷PD-1與其配體(B7-H1和B7-DC)的結(jié)合,并抑制T細(xì)胞增殖和細(xì)胞因子產(chǎn)生。 抗PD-1(RMP 1 -14)-超低內(nèi)毒素該產(chǎn)品同種型對照:Rat IgG2a In Vivo Isotype Control - Ultra Low Endotoxin [1-1] (ICH2244UL) 緩沖液:ICH3001-100ml,nICH3002-100ml,nICH3003-100ml, 濃度:≥ 2.0 mg/ml 純度:>98% by SDS-PAGE and HPLC 內(nèi)毒素:≤ 0.5 EU/mg as determined by the LAL method 制劑:0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added.
應(yīng)用類型
Western Blot, Blocking, Flow Cytometry, Functional Assays