MHC II類抗體,克隆M5/114.15.2,識(shí)別主要組織相容性復(fù)合體(MHC)II類分子I-Ab、I-Ad、I-Aq、I-Ed和I-Ek。MHC II類在專職抗原呈遞細(xì)胞(APC)上組成型表達(dá),包括巨噬細(xì)胞/單核細(xì)胞、樹(shù)突細(xì)胞(DC)和B細(xì)胞,并且在活化后在T細(xì)胞上被誘導(dǎo)。MHC II類由兩個(gè)跨膜蛋白組成,35 kDa的α(重)鏈和29 kDa的β(輕)鏈。N-末端α1和β1結(jié)構(gòu)域形成抗原結(jié)合溝,其結(jié)合來(lái)自外源抗原的13-25個(gè)氨基酸的肽。在APC上,MHC II類通過(guò)將吞噬的抗原呈遞給輔助性CD 4 T細(xì)胞在適應(yīng)性免疫應(yīng)答中起關(guān)鍵作用。CD 4 T細(xì)胞的T細(xì)胞受體(TCR)/CD 3復(fù)合物與肽-MHC II類相互作用,其誘導(dǎo)CD 4 T細(xì)胞活化,導(dǎo)致其他效應(yīng)細(xì)胞的協(xié)調(diào)和調(diào)節(jié)。CD 4分子還結(jié)合到MHC II類,這有助于增強(qiáng)TCR信號(hào)傳導(dǎo)。也已經(jīng)證明,在活化的T細(xì)胞上表達(dá)的MHCII類能夠抗原呈遞并且能夠?qū)⑿盘?hào)傳遞到T細(xì)胞中,從而增強(qiáng)T細(xì)胞增殖和活性。 抗小鼠MHC II類(M5/114.15.2)體內(nèi)抗體-超低內(nèi)毒素該產(chǎn)品同種型對(duì)照:Rat IgG2b In Vivo Isotype Control - Low Endotoxin [1-2] (ICH2243) 緩沖液:ICH3001-100ml,nICH3002-100ml,nICH3003-100ml, 濃度:≥ 5.0 mg/ml 純度:>98% by SDS-PAGE and HPLC 內(nèi)毒素:≤ 0.5 EU/mg as determined by the LAL method 制劑:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.