FasL抗體(克隆AFS 98)識(shí)別Fas配體(FasL),也稱為CD 178、Apo-1配體和CD 95配體。FasL是屬于腫瘤壞死因子(TNF)超家族的40 kDa II型膜整合蛋白。FasL由活化的T細(xì)胞和自然殺傷細(xì)胞(NK細(xì)胞)表達(dá)。FasL與其受體Fas(CD 95,APO-1)的結(jié)合誘導(dǎo)表達(dá)Fas的靶細(xì)胞中的凋亡性細(xì)胞死亡,有助于抗病毒免疫。FasL還通過活化誘導(dǎo)的自分泌和旁分泌T細(xì)胞死亡促進(jìn)外周耐受和免疫應(yīng)答的下調(diào)。FasL也存在于眼睛的前房和睪丸的支持細(xì)胞上,并與這些部位的免疫赦免有關(guān)。FasL還有助于CD 8增殖和中性粒細(xì)胞募集。可溶性FasL(26 kDa)可在金屬蛋白酶切割后釋放,并阻斷FasL介導(dǎo)的信號(hào)傳導(dǎo)。Fas/FasL信號(hào)通路參與了許多人類疾病的發(fā)展,包括自身免疫和癌癥。許多人類腫瘤過度表達(dá)FasL,導(dǎo)致腫瘤浸潤淋巴細(xì)胞(tumor infiltrating lymphocyte,TIL)凋亡和免疫逃避,這與不良預(yù)后相關(guān)。 抗小鼠Fas配體(MFL 3)體內(nèi)抗體-低內(nèi)毒素該產(chǎn)品同種型對(duì)照:Armenian Hamster IgG Isotype Control for In Vivo - Ultra Low Endotoxin [PIP] (ICH2251UL) 緩沖液:ICH3001-100ml,nICH3002-100ml,nICH3003-100ml, 濃度:≥ 5.0 mg/ml 純度:≥95% monomer by analytical SEC, >95% by SDS Page 內(nèi)毒素:<1.0 EU/mg as determined by the LAL method 制劑:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.