谷氨酸脫氫酶抑制劑篩選試劑盒（熒光法）-Glutamate Dehydrogenase Inhibitor Screening Kit (Fluorometric)代理/參數(shù)/廠家-細(xì)胞分析試劑盒-艾美捷科技有限公司

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產(chǎn)品描述: Glutamate dehydrogenase (GDH) (1.4.1.2) is a hexameric enzyme that catalyzes the reversible conversion of glutamate to α-ketoglutarate and ammonia while reducing NAD+ to NADH. Glutamate can be converted to α-ketoglutarate by GDH and then fluxed into the TCA cycle where it can be used to support oxidative phosphorylation, production of lipids, or to replenish key intermediates such as oxaloacetate. It is a key enzyme in the glutamine metabolic pathway. Overexpression of GDH has been shown to promote cell proliferation, migration and invasion in several tumors such as colorectal cancer. The increased reliance on glutamine metabolism makes GDH a target for therapeutic intervention in cancer. GDH inhibitors have been shown to be toxic for cancer cells in vitro. In BioVision’s Glutamate Dehydrogenase inhibitor screening Kit, Glutamate is deaminated by GDH producing NADH, which converts a non-fluorescent probe to a fluorescent product in the presence of enzyme mix that is detected fluorometrically at Ex/Em = 535/587 nm. The kit provides a rapid, simple, sensitive plate based test, which is also suitable for high-throughput screening of GDH inhibitors.

產(chǎn)品特點: Simple, Sensitive plate based test, which is also suitable for high-throughput screening of GDH inhibitors, Rapid

其他: BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學(xué)公司的領(lǐng)導(dǎo)者.BioVision在開發(fā)和研究細(xì)胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關(guān)特色抗體、重組蛋白及細(xì)胞因子和酶等多種產(chǎn)品，以及其他創(chuàng)新的研究工具.其產(chǎn)品覆蓋細(xì)胞凋亡研究、能量代謝、細(xì)胞/組織蛋白提取、氧化應(yīng)激與損傷、代謝與肥胖癥、細(xì)胞增殖與毒性、信號轉(zhuǎn)導(dǎo)、干細(xì)胞研究等領(lǐng)域.作為多家知名品牌的中國總代理以及中國區(qū)域代理，艾美捷與BioVision一起為研究者們提供最好、最新的細(xì)胞生物學(xué)研究工具而不斷擴大產(chǎn)品及服務(wù)質(zhì)量.