- 中文名稱
LDL攝取測定試劑盒（基于細(xì)胞）
- 英文名字
- LDL Uptake Assay Kit (Cell-Based)
- 供應(yīng)商
- Biovision
- 產(chǎn)品貨號
- K436-100
- 產(chǎn)品報(bào)價(jià)
- ￥詢價(jià)/100assays
- 產(chǎn)品說明書
- 點(diǎn)擊查看
- 購買方式
- 銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868.
- 產(chǎn)品新聞
- 背景資料
- 待更新
- 產(chǎn)品描述
- Low-density lipoprotein (LDL) is a large spherical macromolecule that serves as a ‘shuttle’ to transport hydrophobic molecules (lipids and cholesterol) throughout the body via the aqueous environment of the bloodstream. An LDL particle consists of a hydrophobic core of cholesterol esters (with long-chain fatty acids linked to the hydroxyl group) and triglycerides surrounded by an amphipathic shell containing the 510 kDa protein Apolipoprotein B-100, various phospholipids and non-esterified cholesterol molecules. LDL is taken up by cells such as hepatocytes, macrophages, and endothelial cells by specific receptor-mediated endocytosis. High levels of LDL have been associated with arterial inflammation, which leads to cardiovascular diseases (CVD) like atherosclerosis, ischemic stroke and myocardial infarction. LDL particles can migrate through inflamed vascular endothelial tight junctions, where they become oxidized and attract circulating monocytes. Monocytes differentiate into activated macrophages, which further accumulate LDL and become foam cells, leading to arterial wall thickening/scaring and formation of fibrous fatty plaques. Current CVD preventative therapies include decreasing LDL with statins, which prevent endogenous cholesterol biosynthesis by inhibiting HMG-CoA reductase. However, drugs that inhibit LDL uptake by macrophages or enhance LDL clearance by increasing hepatic LDL reuptake are also being investigated. BioVision’s LDL Uptake Assay Kit enables measurement of receptor-mediated LDL uptake by various cell types. The kit contains fluorescent human LDL, which is covalently-labeled with a bright, highly photostable fluorophore that can be detected when taken up by cells (Ex/Em = 488/523 nm). Unlabeled human LDL is included in the kit for validation of specific labeled LDL uptake. The kit contains a complete set of reagents sufficient for performing 100 reactions and a 96-well polylysine-coated black cell culture plate with a thin, microscopy-grade clear bottom.
- 產(chǎn)品特點(diǎn)
- Measure LDL uptake in different cell types,Non-Radioactive,Contains fluorescent human LDL, which is covalently-labeled with a bright, highly photostable fluorophore,Screen, study or characterize stimulators or inhibitors of LDL uptake
- 保存建議
- -20
- 其他
- BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學(xué)公司的領(lǐng)導(dǎo)者.BioVision在開發(fā)和研究細(xì)胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關(guān)特色抗體、重組蛋白及細(xì)胞因子和酶等多種產(chǎn)品，以及其他創(chuàng)新的研究工具.其產(chǎn)品覆蓋細(xì)胞凋亡研究、能量代謝、細(xì)胞/組織蛋白提取、氧化應(yīng)激與損傷、代謝與肥胖癥、細(xì)胞增殖與毒性、信號轉(zhuǎn)導(dǎo)、干細(xì)胞研究等領(lǐng)域.作為多家知名品牌的中國總代理以及中國區(qū)域代理，艾美捷與BioVision一起為研究者們提供最好、最新的細(xì)胞生物學(xué)研究工具而不斷擴(kuò)大產(chǎn)品及服務(wù)質(zhì)量.
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- 注意
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該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。
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