人肌苷5'-單磷酸脫氫酶（IMPDH）抑制劑篩選測(cè)定試劑盒-Human Inosine-5’-Monophosphate Dehydrogenase (IMPDH) Inhibitor Screening Assay Kit代理/參數(shù)/廠家-細(xì)胞分析試劑盒-艾美捷科技有限公司

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英文名字: Human Inosine-5’-Monophosphate Dehydrogenase (IMPDH) Inhibitor Screening Assay Kit

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產(chǎn)品描述: Inosine monophosphate dehydrogenase, IMPDH, (E.C. 1.1.1.205) is the rate-limiting enzyme in de novo guanine nucleotide biosynthesis and it is essential for lymphocyte proliferation. IMPDH oxidizes inosine 5’-monophosphate (IMP) to xanthine 5’-monophosphate (XMP) using NAD as a cofactor. It plays a critical role in cell growth and in the malignancy of some tumors such as pancreatic, colon and bladder cancers. IMPDH2 is the predominant isoform of IMPDH and is specifically linked to a wide range of cancers and lymphocyte proliferation. IMPDH is recognized as a validated target as antiviral, antiparasitic, antimicrobial, antileukemic and immunosuppressive agents. In BioVison’s IMPDH inhibitor screening assay, IMP is oxidized by IMPDH producing a series of intermediates, which react with the probe to generate a colorimetric signal (OD 450 nm). The signal is directly proportional to the IMPDH activity and has a very low background. In the presence of a IMPDH inhibitor such as mycophenolic acid (MPA), the reaction is arrested, thus decreasing the signal. BioVision’s IMPDH assay is fast, sensitive and reproducible and is suitable for functional assays, high-throughput screening and preclinical studies in drug discovery.

產(chǎn)品特點(diǎn): ? Simple and reliable test to screen IMPDH inhibitors/activators ? High-throughput compatible ? Includes Inhibitor Control (MPA)

其他: BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學(xué)公司的領(lǐng)導(dǎo)者.BioVision在開(kāi)發(fā)和研究細(xì)胞凋亡檢測(cè)分析、代謝檢測(cè)方面具有卓越的影響力.包括檢測(cè)各種檢測(cè)分析試劑盒、相關(guān)特色抗體、重組蛋白及細(xì)胞因子和酶等多種產(chǎn)品，以及其他創(chuàng)新的研究工具.其產(chǎn)品覆蓋細(xì)胞凋亡研究、能量代謝、細(xì)胞/組織蛋白提取、氧化應(yīng)激與損傷、代謝與肥胖癥、細(xì)胞增殖與毒性、信號(hào)轉(zhuǎn)導(dǎo)、干細(xì)胞研究等領(lǐng)域.作為多家知名品牌的中國(guó)總代理以及中國(guó)區(qū)域代理，艾美捷與BioVision一起為研究者們提供最好、最新的細(xì)胞生物學(xué)研究工具而不斷擴(kuò)大產(chǎn)品及服務(wù)質(zhì)量.

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