精氨酸酶I（ARG1）抑制劑篩選試劑盒（比色）-Arginase I (ARG1) Inhibitor Screening Kit (Colorimetric)代理/參數(shù)/廠家-細胞分析試劑盒-艾美捷科技有限公司

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產(chǎn)品描述: Arginase (EC 3.5.3.1) is a manganese-containing enzyme which catalyzes the conversion of arginine into urea and ornithine, which is the final reaction in the urea cycle. Arginase I (ARG1) is the liver isoform of arginase. Recent studies showed that ARG1 expression by mature myeloid cells in tumor environment as demonstrated in a 3LL murine lung carcinoma model causes L-Arginine depletion by tumor-associated myeloid cells (TAMC). L-arginine depletion suppresses immune-response against tumor cells due to inhibition to T-cell proliferation. In addition, the depletion of arginine increases the reactive nitrogen species (NOS) and reactive oxygen species (ROS), which, in consequence, induce T-cell apoptosis and supports antigenic cell proliferation. BioVision’s Arginase I (ARG1) Inhibitor Screening Kit is designed for screening ARG1 inhibitors. Two substituted-2-amino-6-hexanoic acids have been studied as arginase inhibitor and in this kit, Amino-2-Borono-6-Hexanoic Acid (ABH) is provided as a positive control. The ARG1 activity is monitored by the increase in absorbance readings (OD 450 nm), while potential inhibitors will cause a decrease of absorbance. The assay kit is simple, quick and can be used to identify and characterize ARG1 inhibitors in a high-throughput format

產(chǎn)品特點: Sensitive assay for the screening of potential human ARG1 inhibitors

其他: BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學(xué)公司的領(lǐng)導(dǎo)者.BioVision在開發(fā)和研究細胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關(guān)特色抗體、重組蛋白及細胞因子和酶等多種產(chǎn)品，以及其他創(chuàng)新的研究工具.其產(chǎn)品覆蓋細胞凋亡研究、能量代謝、細胞/組織蛋白提取、氧化應(yīng)激與損傷、代謝與肥胖癥、細胞增殖與毒性、信號轉(zhuǎn)導(dǎo)、干細胞研究等領(lǐng)域.作為多家知名品牌的中國總代理以及中國區(qū)域代理，艾美捷與BioVision一起為研究者們提供最好、最新的細胞生物學(xué)研究工具而不斷擴大產(chǎn)品及服務(wù)質(zhì)量.