- 中文名稱(chēng)
【干冰】NFKB ANTIBODY SAMPLER KIT - K711
- 英文名字
- 【干冰】NFKB ANTIBODY SAMPLER KIT - K711
- 供應(yīng)商
- Rockland
- 產(chǎn)品貨號(hào)
- K711
- 產(chǎn)品報(bào)價(jià)
- ￥詢(xún)價(jià)/1Kit
- 產(chǎn)品說(shuō)明書(shū)
- 點(diǎn)擊查看
- 購(gòu)買(mǎi)方式
- 90%產(chǎn)品中國(guó)有現(xiàn)貨庫(kù)存。銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868
- 產(chǎn)品新聞
- 背景資料
- NFKB was originally identified as a factor that binds to the immunoglobulin kappa light chain enhancer in B cells. It was subsequently found in non-B cells in an inactive cytoplasmic form consisting of NFkB bound to IkB. NFkB was originally identified as a heterodimeric DNA binding protein complex consisting of p65 (RelA) and p50 (NFKB1) subunits. Other identified subunits include p52 (NFKB2), c-Rel, and RelB. The p65, cRel, and RelB subunits are responsible for transactivation. The p50 and p52 subunits possess DNA binding activity but limited ability to transactivate. p52 has been reported to form transcriptionally active heterodimers with the NFkB subunit p65, similar to p50/p65 heterodimers. The heterodimers of p52/p65 and p50/p65 are regulated by physical inactivation in the cytoplasm by IkB-a. IkB-a binds to the p65 subunit, preventing nuclear localization and DNA binding. Low levels of p52 and p50 homodimers can also exist in cells.
IKB-alpha inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, IKBA becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Anti-NFkB and Anti-IKBa Antibodies are ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction and Immunology research.
- 產(chǎn)品描述
- Each kit contains one unit of the following products:
Anti-NFKB p50 (NFKB1) (RABBIT) Antibody (100 μL)
Anti-NFKB p65 (Rel A) (RABBIT) Antibody (100 μL)
Anti-NFKB cRel (RABBIT) Antibody (100 μL)
Anti-IKBα C-terminal (RABBIT) Antibody (100 μL)
Anti-RABBIT IgG (H&L) (GOAT) Peroxidase Conjugated Antibody (100 μg)
CONTROL PEPTIDE for Anti-NFKB p50 (NFKB1) (RABBIT) Antibody (50 μg)
CONTROL PEPTIDE for Anti-NFKB p65 (Rel A) (RABBIT) Antibody (50 μg)
CONTROL PEPTIDE for Anti-NFKB cRel (RABBIT) Antibody (50 μg)
CONTROL PEPTIDE for Anti-IKBα C-terminal (RABBIT) Antibody ( (50 μg)
- 產(chǎn)品特點(diǎn)
- 該【干冰】NFKB ANTIBODY SAMPLER KIT - K711的詳細(xì)信息查看Rockland提供的產(chǎn)品說(shuō)明書(shū)。
- 保存建議
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
- 其他
- Rockland成立于1962年，是一家老牌抗體原產(chǎn)企業(yè)，其位于美國(guó)費(fèi)城郊區(qū)的農(nóng)場(chǎng)保有近20種實(shí)驗(yàn)動(dòng)物。Rockland公司為生命科學(xué)領(lǐng)域提供豐富的、高質(zhì)量的抗體，包括載脂蛋白、細(xì)胞周期/凋亡、細(xì)胞因子、細(xì)胞信號(hào)蛋白、酶類(lèi)、細(xì)胞外基質(zhì)、轉(zhuǎn)錄因子(NFkB)和泛素（Ubiquitin）等識(shí)別抗體，應(yīng)用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產(chǎn)特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標(biāo)記二抗，應(yīng)用十分廣泛。
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- 注意
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該頁(yè)面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請(qǐng)以廠家的英文說(shuō)明書(shū)為準(zhǔn)。下單前，請(qǐng)瀏覽說(shuō)明書(shū)確認(rèn)。
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