- 中文名稱
Phospho-p53（Ser15）易位測定試劑盒（基于細(xì)胞）
- 英文名字
- Phospho-p53 (Ser15) Translocation Assay Kit (Cell-Based)
- 供應(yīng)商
- Biovision
- 產(chǎn)品貨號
- K966-50
- 產(chǎn)品報(bào)價(jià)
- ￥詢價(jià)/50assays
- 產(chǎn)品說明書
- 點(diǎn)擊查看
- 購買方式
- 銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線支付寶及網(wǎng)銀支付，或直接與我們電話聯(lián)系400-6800-868.
- 產(chǎn)品新聞
- 背景資料
- 待更新
- 產(chǎn)品描述
- Tumor protein p53 (TP53, p53) is a widely conserved transcription factor and tumor suppressor commonly referred to as the “guardian of the genome”. Due to the presence of transcriptional activation, DNA binding, and oligomerization domains, p53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in p53 gene are associated with numerous human cancers and about 50% of those mutations result in loss of function. Multiple genotoxic and non-genotoxic stimuli lead to stabilization and activation of p53 that are mediated by numerous post-translational modifications. The N-terminus of p53 is heavily phosphorylated, whereas the C-terminus may be phosphorylated, acetylated neddylated, ubiquitinated or sumoylated. In unstressed cells, the level of p53 protein is downregulated via binding to MDM2, COP1, PIRH2 or JNK that promote p53 degradation. Cellular stress and Nutlin-3, a potent inhibitor of Mdm2-p53 interaction, activate and increase level of p53 in the cell due to lack of negative regulation. Presence of three putative nuclear localization signals (NLSs) on its C-terminus, promotes translocation of some of the activated p53 into the nucleus thus activating genes that induce cell cycle arrest, senescence, or apoptosis. BioVision’s Phospho-p53 (Ser15) Translocation Assay Kit provides a simple and complete assay in a ready to use format to visualize the nuclear translocation of activated p53 in mammalian cells.
- 產(chǎn)品特點(diǎn)
- Detection of nuclear translocation of phosphorylated p53 in mammalian cells
Characterize/Screen/Study for effectors of p53 cellular levels
Detection of cellular stress or DNA damage caused by genotoxic and non-genotoxic stimuli
- 保存建議
- -20
- 其他
- BioVision的公司總部在美麗的舊金山灣地區(qū)，它是全球生命科學(xué)公司的領(lǐng)導(dǎo)者.BioVision在開發(fā)和研究細(xì)胞凋亡檢測分析、代謝檢測方面具有卓越的影響力.包括檢測各種檢測分析試劑盒、相關(guān)特色抗體、重組蛋白及細(xì)胞因子和酶等多種產(chǎn)品，以及其他創(chuàng)新的研究工具.其產(chǎn)品覆蓋細(xì)胞凋亡研究、能量代謝、細(xì)胞/組織蛋白提取、氧化應(yīng)激與損傷、代謝與肥胖癥、細(xì)胞增殖與毒性、信號轉(zhuǎn)導(dǎo)、干細(xì)胞研究等領(lǐng)域.作為多家知名品牌的中國總代理以及中國區(qū)域代理，艾美捷與BioVision一起為研究者們提供最好、最新的細(xì)胞生物學(xué)研究工具而不斷擴(kuò)大產(chǎn)品及服務(wù)質(zhì)量.
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- 注意
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該頁面的中文產(chǎn)品信息的翻譯，僅供參考。準(zhǔn)確的產(chǎn)品信息請以廠家的英文說明書為準(zhǔn)。下單前，請瀏覽說明書確認(rèn)。
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