中文名稱(chēng)

NDRG1重組蛋白

英文名字

NDRG1 Recombinant Protein

供應(yīng)商

Bioworld

產(chǎn)品貨號(hào)

NCP0437

產(chǎn)品報(bào)價(jià)

￥詢(xún)價(jià)/500ug

產(chǎn)品說(shuō)明書(shū)

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購(gòu)買(mǎi)方式

銀行轉(zhuǎn)賬、電匯、支票、現(xiàn)金，在線(xiàn)支付寶及網(wǎng)銀支付，或直接與我們電話(huà)聯(lián)系400-6800-868

產(chǎn)品新聞

背景資料

N-myc downstream-regulated gene 1 (NDRG1), also termed Cap43, Drg1, RTP/rit42, and Proxy-1, is a member of the NDRG family, which is composed of four members (NDRG1-4) that function in growth, differentiation, and cell survival. NDRG1 is ubiquitously expressed and highly responsive to a variety of stress signals, including DNA damage, hypoxia, and elevated levels of nickel and calcium. Expression of NDRG1 is elevated in N-myc defective mice and is negatively regulated by N- and c-myc. During DNA damage, NDRG1 is induced in a p53-dependent fashion and is necessary for p53-mediated apoptosis. Research studies have shown that NDRG1 may also play a role in cancer progression by promoting differentiation, inhibiting growth, and modulating metastasis and angiogenesis. Nonsense mutation of the NDRG1 gene has been shown to cause hereditary motor and sensory neuropathy-Lom (HMSNL), which is supported by studies demonstrating the role of NDRG1 in maintaining myelin sheaths and axonal survival. NDRG1 is upregulated during mast cell maturation and its deletion leads to attenuated allergic responses. Both NDRG1 and NDRG2 are substrates of SGK1, although the precise physiological role of SGK1-mediated phosphorylation is not known. NDRG1 is phosphorylated by SGK1 at Thr328, Ser330, Thr346, Thr356, and Thr366. Phosphorylation by SGK1 primes NDRG1 for phosphorylation by GSK-3.

序列

HMSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYPSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGAAGNSAGPKSMEVSCLE

來(lái)源宿主

E.coli

溶解建議

PBS, PH7.4

保存建議

Store at 4

其他

Bioworld是專(zhuān)一服務(wù)于生命科學(xué)研究的專(zhuān)業(yè)技術(shù)型企業(yè)，Bioworld品牌創(chuàng)立以來(lái)?yè)碛?0000多種常規(guī)產(chǎn)品現(xiàn)貨，現(xiàn)有8000多種現(xiàn)貨抗體，以及其他IVD原料，蛋白等現(xiàn)貨產(chǎn)品。在細(xì)胞信號(hào)通路、免疫學(xué)、蛋白組學(xué)上擁有顯著優(yōu)勢(shì)，其抗體產(chǎn)品、生長(zhǎng)因子、IVD原料等為生命科學(xué)科研工作者提供了極大的便利

注意

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