Rabbit IgG polyclonal antibody for cGKI/PRKG1 detection. Tested with WB, IHC, ICC/IF, FCM, Direct ELISA in Human;Mouse;Rat.-Rabbit IgG polyclonal antibody for cGKI/PRKG1 detection. Tested with WB, IHC, ICC/IF, FCM, Direct ELISA in Human;Mouse;Rat.代理/參數(shù)/廠(chǎng)家-一抗-艾美捷科技有限公司

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中文名稱(chēng): Rabbit IgG polyclonal antibody for cGKI/PRKG1 detection. Tested with WB, IHC, ICC/IF, FCM, Direct ELISA in Human;Mouse;Rat.

英文名字: Rabbit IgG polyclonal antibody for cGKI/PRKG1 detection. Tested with WB, IHC, ICC/IF, FCM, Direct ELISA in Human;Mouse;Rat.

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背景資料: cGMP-dependent protein kinase 1, alpha isozyme is an enzyme that in humans is encoded by the PRKG1 gene. Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.

免疫原: E.coli-derived human cGKI/PRKG1 recombinant protein (Position: S2-Q44).

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