Rabbit IgG polyclonal antibody for CIITA detection. Tested with WB, FCM, Direct ELISA in Human;Mouse;Rat.-Rabbit IgG polyclonal antibody for CIITA detection. Tested with WB, FCM, Direct ELISA in Human;Mouse;Rat.代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: Rabbit IgG polyclonal antibody for CIITA detection. Tested with WB, FCM, Direct ELISA in Human;Mouse;Rat.

英文名字: Rabbit IgG polyclonal antibody for CIITA detection. Tested with WB, FCM, Direct ELISA in Human;Mouse;Rat.

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背景資料: CIITA is a human gene which is mapped to 16p13. This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. Also, the protein binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene.

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