Amyloid-precursor-like protein 1(APLP1) is a membrane-associated glycoprotein, whose gene is homologous to the APP gene, which has been shown to be involved in the pathogenesis of Alzheimer's disease. APLP1 is predominantly expressed in brain, particularly in the cerebral cortex postsynaptic absorbance. The human gene has been mapped to chromosomal region 19q13.1. The gene is 11.8 kb long and contains 17 exons. APLP1 has been considered a candidate gene for CNF. All exon regions of the gene were amplified by the polymerase chain reaction and sequenced from DNA of CNF patients. No differences were observed between CNF patients and controls, suggesting that mutations in APLP1 are not involved in the etiology of CNF.
應(yīng)用類型
IHC,WB
免疫原
A synthetic peptide corresponding to a sequence at the N-terminus of human APLP1(101-120aa ELQIARVEQATQAIPMERWC), different from the related mouse and rat sequences by two amino acids.