- 中文名稱
Rabbit IgG polyclonal antibody for Serine-protein kinase ATM(ATM) detection. Tested with WB in Human;Mouse;Rat.
- 英文名字
- Rabbit IgG polyclonal antibody for Serine-protein kinase ATM(ATM) detection. Tested with WB in Human;Mouse;Rat.
- 供應(yīng)商
- Nordic BioSite
- 產(chǎn)品貨號(hào)
- NDC-ABB-N66F0H-100
- 產(chǎn)品報(bào)價(jià)
- ￥詢價(jià)/100ug
- 產(chǎn)品說明書
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- 購(gòu)買方式
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- 產(chǎn)品新聞
- 背景資料
- ATM(ataxia telangiectasia mutated),also known as TEL1 or TELO1, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. The ATM protein is a member of the phosphatidylinositol 3-kinase family of proteins that respond to DNA damage by phosphorylating key substrates involved in DNA repair and/or cell cycle control. Linkage analysis of ataxia-telangiectasia led to mapping of the ATM gene to chromosome 11q22.3. Using an antiserum developed to a peptide corresponding to the deduced amino acid sequence of ATM, the ATM protein is a single, high molecular weight protein predominantly confined to the nucleus of human fibroblasts, although it is present in both nuclear and microsomal fractions from human lymphoblast cells and peripheral blood lymphocytes. Overexpression of ATM cDNA in AT cells enhanced their survival after radiation exposure, decreased radiation-induced chromosome aberrations, reduced radioresistant DNA synthesis, and partially corrected defective cell cycle checkpoints and induction of stress-activated protein kinase. ATM has an essential role in the reconstitutive capacity of hematopoietic stem cells but is not as important for the proliferation or differentiation of progenitors, in a telomere-independent manner. ATM functions directly in the repair of chromosomal DNA double-stranded breaks by maintaining DNA ends in repair complexes generated during lymphocyte gene assembly.
- 應(yīng)用類型
- WB
- 免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human ATM(36-50aa DPETIKHLDRHSDSK), different from the related rat and mouse sequences by two amino acids.
- 來源宿主
- rabbit
- 反應(yīng)性
- human,mouse,rat
- 保存建議
- -20
- 其他
- Nordic BioSite(北歐生物) 總部位于瑞典，成立于1997年，旨在分銷研究和診斷領(lǐng)域的高質(zhì)量和創(chuàng)新產(chǎn)品。 Nordic BioSite 被公認(rèn)為整個(gè)北歐生物醫(yī)學(xué)研究和診斷產(chǎn)品領(lǐng)域的領(lǐng)導(dǎo)者。他們擁有超過570萬種的產(chǎn)品組合，代理了遍布?xì)W洲和美國(guó)的頂級(jí)生物試劑制造商，是歐洲知名的一站式生物試劑代理商。除了作為分銷商之外，Nordic BioSite 還擁有不斷增長(zhǎng)的自產(chǎn)產(chǎn)品線——BioSite mAb、BioSite ELISA、BioSite Flow、Optibodies和 BioSite Protein, 目前艾美捷代理的是Nordic BioSite自產(chǎn)產(chǎn)品線(共26W+產(chǎn)品)。Nordic BioSite的產(chǎn)品類型主要是抗體，蛋白和試劑盒，產(chǎn)品適用范圍涵蓋15個(gè)不同的物種(人，牛，犬，鯰魚，雞，海豚，馬，貓，豚鼠，小鼠，綿羊，兔子，大鼠，豬和火雞)，可為您提供一站式的生命科學(xué)研究解決方案~
- 注意
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