Rabbit IgG polyclonal antibody for 5-hydroxytryptamine receptor 1A(HTR1A) detection. Tested with WB, IHC in Human;Mouse;Rat.-Rabbit IgG polyclonal antibody for 5-hydroxytryptamine receptor 1A(HTR1A) detection. Tested with WB, IHC in Human;Mouse;Rat.代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: Rabbit IgG polyclonal antibody for 5-hydroxytryptamine receptor 1A(HTR1A) detection. Tested with WB, IHC in Human;Mouse;Rat.

英文名字: Rabbit IgG polyclonal antibody for 5-hydroxytryptamine receptor 1A(HTR1A) detection. Tested with WB, IHC in Human;Mouse;Rat.

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背景資料: HTR1A(5-HYDROXYTRYPTAMINE RECEPTOR 1A), also called SEROTONIN 5-HT-1A RECEPTOR or BETA-2-ADRENERGIC RECEPTOR-LIKE PROTEIN G-21, is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor(GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. HTR1A denotes the human gene encoding for the receptor.The HTR1A gene is located at 5q12.3. The decreases in 5-HT-1A receptor densities correlated with decreased glucose utilization as measured by PET scan. Activation of 5-HT-1A receptors has been demonstrated to impair cognition, learning, and memory by inhibiting the release of glutamate and acetylcholine in various areas of the brain. 5-HT-1A receptors in the dorsal raphe nucleus are co-localized with neurokinin 1(NK1) receptors and have been shown to inhibit the release of substance P, their endogenous ligand.

免疫原: A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT1A Receptor(404-422aa NKDFQNAFKKIIKCKFCRQ), different from the related rat and mouse sequences by one amino acid.

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