Rabbit IgG polyclonal antibody for B-cell lymphoma/leukemia 10(BCL10) detection. Tested with WB in Human;Rat.-Rabbit IgG polyclonal antibody for B-cell lymphoma/leukemia 10(BCL10) detection. Tested with WB in Human;Rat.代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: Rabbit IgG polyclonal antibody for B-cell lymphoma/leukemia 10(BCL10) detection. Tested with WB in Human;Rat.

英文名字: Rabbit IgG polyclonal antibody for B-cell lymphoma/leukemia 10(BCL10) detection. Tested with WB in Human;Rat.

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背景資料: BCL10, B-cell CLL/lymphoma 10, gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The BCL10 gene is mapped to chromosome 1p22. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. And this protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

免疫原: E.coli-derived human Bcl10 recombinant protein (Position: M1-Q233). Human Bcl10 shares 91% and 91.4% amino acid (aa) sequence identity with mouse and rat Bcl10, respectively.

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