Rabbit IgG polyclonal antibody for DNA polymerase eta(POLH) detection. Tested with WB, IHC, ICC/IF, FCM in Human;Rat.-Rabbit IgG polyclonal antibody for DNA polymerase eta(POLH) detection. Tested with WB, IHC, ICC/IF, FCM in Human;Rat.代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: Rabbit IgG polyclonal antibody for DNA polymerase eta(POLH) detection. Tested with WB, IHC, ICC/IF, FCM in Human;Rat.

英文名字: Rabbit IgG polyclonal antibody for DNA polymerase eta(POLH) detection. Tested with WB, IHC, ICC/IF, FCM in Human;Rat.

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背景資料: DNA polymerase eta (Pol η), is a protein that in humans is encoded by the POLH gene. This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.

免疫原: E.coli-derived human POLH recombinant protein (Position: A157-R361). Human POLH shares 93.6% amino acid (aa) sequence identity with mouse POLH.

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