Rabbit IgG polyclonal antibody for Crk-like protein(CRKL) detection. Tested with WB, ICC/IF in Human;Mouse;Rat.-Rabbit IgG polyclonal antibody for Crk-like protein(CRKL) detection. Tested with WB, ICC/IF in Human;Mouse;Rat.代理/參數(shù)/廠家-一抗-艾美捷科技有限公司

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中文名稱: Rabbit IgG polyclonal antibody for Crk-like protein(CRKL) detection. Tested with WB, ICC/IF in Human;Mouse;Rat.

英文名字: Rabbit IgG polyclonal antibody for Crk-like protein(CRKL) detection. Tested with WB, ICC/IF in Human;Mouse;Rat.

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背景資料: CRKL(v-crk sarcoma virus CT10 oncogene homolog(avian)-like) also called ONCOGENE CRKL, encodes a 303-amino acid polypeptide with a predicted molecular mass of 36 kD. While CRKL is not the human homolog of CRK, it is similar to protein-tyrosine kinases with SH2 and SH3(src homology) domains. By fluorescence in situ hybridization, the CRKL gene is localized to chromosome 22q11, centromeric of the chronic myelogenous leukemia breakpoint region. Senechal et al.(1996) showed that CRKL becomes phosphorylated when overexpressed, activates Ras-dependent and JNK pathways, and transforms fibroblasts. The authors also found CRKL to be a substrate for the BCR-ABL tyrosine kinase, leading them to conclude thatCRKL is a tyrosine kinase and an oncogene. Crkl was required for normal cellular responses to Fgf8, including survival and migration, Erk activation, and target gene expression.

免疫原: A synthetic peptide corresponding to a sequence at the C-terminus of human CrkL(286-303aa FPFTHVKIFDPQNPDENE), different from the related mouse and rat sequences by one amino acid.

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